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(newest | oldest) View (newer 50 | older 50) (20 | 50 | 100 | 250 | 500)- 13:56, 14 September 2023 Aidan talk contribs created page Good Clinical Practices (Created page with "* Regulations guiding clinical research in Canada * See also [https://www.canada.ca/en/health-canada/services/drugs-health-products/compliance-enforcement/good-clinical-practices.html Good Clinical Practices (Health Canada)] Category:Research") Tag: Visual edit
- 13:54, 14 September 2023 Aidan talk contribs created page GCP (Redirected page to Good Clinical Practices) Tags: New redirect Visual edit
- 13:39, 14 September 2023 Aidan talk contribs created page Investigator (Created page with "* In the context of clinical research in Canada, an '''investigator''' is a person responsible for the conduct of a clinical trial at a trial site ** If research at the site includes a team, the investigator is the responsible leader and may also be referred to as the principal investigator or qualified investigator * A '''principal investigator''' is US terminology, not applicable in Canada * A '''qualified investigator''' is defined by Health Canada as the person respo...") Tag: Visual edit
- 13:24, 14 September 2023 Aidan talk contribs created page Adverse event (Created page with "* Any untoward medical occurrence in a patient or research participant who is receiving a treatment * Does not necessarily have a causal relationship with the treatment Category:Research") Tag: Visual edit
- 13:22, 14 September 2023 Aidan talk contribs created page AE (Redirected page to Adverse event) Tags: New redirect Visual edit
- 13:20, 14 September 2023 Aidan talk contribs moved page Adverse antimicrobial reactions to Adverse antimicrobial reaction without leaving a redirect
- 13:19, 14 September 2023 Aidan talk contribs moved page Adverse drug reactions to Adverse drug reaction without leaving a redirect
- 13:18, 14 September 2023 Aidan talk contribs created page ADR (Redirected page to Adverse drug reaction) Tags: New redirect Visual edit
- 18:13, 30 August 2023 Aidan talk contribs created page Splenic hydatid cyst (Created page with "== Background == * Infection with Echinococcus granulosus of the liver == Differential Diagnosis == * Epidermoid cyst * Splenic pseudocyst * Splenic abscess * Splenic hematoma * Intrasplenic pancreatic pseudocyst * Cystic neoplasm of the spleen == Diagnosis == * Ultrasound and CT are best tests but appearance varies widely ** Most common appearance on ultrasound is an anechoic, smooth, round cyst ** Daughter cysts may be present ** May be able to see layers of m...") Tag: Visual edit
- 17:18, 30 August 2023 Aidan talk contribs created page Anisocoria (Created page with "== Background == * Pupils of different sizes * Usual pathophysiology includes imbalance of efferent autonomic nerves ** Parasympathetic causes miosis/constriction and sympathetic causes mydriasis/dilatation * Other cause is mechanical == Etiologies == * Greater difference in dim light ** Horner syndrome, with ipsilateral miosis, ptosis, anhidrosis, enopthalmos, and lack of ciliospinal reflex ** Cholinergic medications, such as pilocarpine to treat glaucoma...") Tag: Visual edit
- 14:11, 26 August 2023 Aidan talk contribs created page SVC syndrome (Redirected page to Superior vena cava syndrome) Tags: New redirect Visual edit
- 19:22, 24 August 2023 Aidan talk contribs added prefix "wikijc" (https://www.wikijournalclub.org/wiki/$1) (trans: 0; local: 0) to the interwiki table
- 19:18, 24 August 2023 Aidan talk contribs added prefix "microbewiki" (https://microbewiki.kenyon.edu/index.php/$1) (trans: 0; local: 0) to the interwiki table
- 19:15, 24 August 2023 Aidan talk contribs added prefix "physio-pedia" (https://www.physio-pedia.com/$1) (trans: 0; local: 0) to the interwiki table
- 13:32, 24 August 2023 Aidan talk contribs created page Clofazimine (Created page with "== Background == * Antibiotic * Indicated for leprosy and non-tuberculous mycobacteria * Has never been studied in an RCT * Mechanism of action is postulated to be redox cycling and memrane destabilization and dysfunction == Safety == === Adverse Effects === * Skin darkening: exposure-related, onset is gradual. Not permanent, will slowly resolve after stopping the drug. * Dry skin and generalized pruritus * QT prolongation and possibly torsades de pointes...") Tag: Visual edit
- 13:35, 23 August 2023 Aidan talk contribs created page Leukoerythroblastic reaction (Created page with "== Background == * A finding on peripheral blood film that is characterized by the presence of immature erythroid cells and myeloid precursors (metamyelocytes, myelocytes, promyelocytes, myeloblasts, and blasts) as well as, exclusively in myelofibrotic disorders, teardrop cells in the peripheral blood == Etiologies == * Malignancy (60%) ** Solid organ (40%) ** Hematologic (20%) * Benign (40%) ** Hemolysis ** Myeloproliferative disease ** Infection ** Hemor...") Tag: Visual edit
- 17:52, 16 August 2023 Aidan talk contribs created page Neutropenia (Created page with "== Etiologies == === Congenital === * Constitutional neutropenia: mild (ANC>1000), chronic * Benign ethnic neutropenia: mild (ANC>1000), chronic, usually in patients with Mediterranean or African ancestry * Benign familial neutropenia: same as above, but hereditary and not associated with a specific ethnicity * Cyclic neutropenia: hereditary, with severe neutropenia on a 21-day cycle since childhood * Others: severe congenital neutropenia, Schwachman-Diamond sy...") Tag: Visual edit
- 14:05, 16 August 2023 Aidan talk contribs created page Drug-induced neutropenia (Created page with "{| class="wikitable sortable" !Class !Drug !Frequency reported !Nature of reaction |- | rowspan="7" |Antibiotics |Semisynthetic penicillins (amoxicillin, ampicillin) |Moderate |Both |- |Cephalosporins |Moderate |Both |- |Vancomycin |High |Both |- |Macrolides |Low |Neutropenia |- |TMP-SMX |High |Agranulocytosis |- |Dapsone |High |Agranulocytosis |- |Chloramphenicol |High |Agranulocytosis |- | rowspan="2" |Antifungals |Amphotericin |Low |Neutropenia |- |Flucytosine |...") Tag: Visual edit
- 13:59, 16 August 2023 Aidan talk contribs created page Cyclic neutropenia (Created page with "== Background == * Rare congenital disease * Autosomal dominant from mutations in ''ELANE'' gene == Clinical Manifestations == * Cycles of severe neutropenia approximately every 21 days (range 2 to 5 weeks) * Duration of neutropenia varies by patient but is consistent for each patient * Usually mild syndrome, though some can develop aphthous ulcers during the nadir Category:Hematology") Tag: Visual edit
- 19:26, 11 August 2023 Aidan talk contribs created page Ochrobactrum (Created page with "==Background== *Genus of Stain::Gram-negative bacilli ==Further Reading== * The Genus ''Ochrobactrum'' as Major Opportunistic Pathogens. Microorganisms. 2020 Nov 16;8(11):1797. doi: 10.3390/microorganisms8111797. PMID: 33207839; PMCID: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696743/ PMC7696743].")
- 14:03, 9 August 2023 Aidan talk contribs created page Pazopanib (Created page with "* Tyrosine kinase inhibitor * Indicated for renal cell carcinoma and soft tissue sarcoma Category:Tyrosine kinase inhibitors") Tag: Visual edit
- 14:02, 9 August 2023 Aidan talk contribs created page Votrient (Redirected page to Pazopanib) Tags: New redirect Visual edit
- 14:00, 9 August 2023 Aidan talk contribs created page Suprax (Redirected page to Cefixime) Tags: New redirect Visual edit
- 14:23, 28 July 2023 Aidan talk contribs created page Parvimonas micra (Created page with "{{DISPLAYTITLE:''Parvimonas micra''}} == Background == * Stain::Gram-positive Cellular respiration::anaerobic Shape::coccus * Commensal member of the gut microbiota, occasionally urogenital tract and skin == Clinical Manifestations == * Chronic apical periodontitis * Bacteremia<ref>Watanabe, T., Hara, Y., Yoshimi, Y. ''et al.'' Clinical characteristics of bloodstream infection by ''Parvimonas micra'': retrospective case series and literature review. '...") Tag: Visual edit
- 16:54, 27 July 2023 Aidan talk contribs created page Anaerobiospirillum succiniciproducens (Created page with "{{DISPLAYTITLE:''Anaerobiospirillum succiniciproducens''}} * Spiral Stain::Gram-negative Shape::bacillus * GI flora of cats and dogs * Rare cases of bacteremia and diarrhea in humans, usually immunocompromised * Likely susceptible to beta lactams, can be resistant to metronidazole ** Beta lactam/beta lactamase combination is most reliable ** Ceftriaxone likely also reliable == Further Reading == * Bloodstream infection with Anaerobiospirillum succinici...") Tag: Visual edit
- 15:36, 26 July 2023 Aidan talk contribs created page RVD (Created page with "* Combination of lenalidomide, bortezomib, and dexamethasone * Indicated for multiple myeloma")
- 13:49, 25 July 2023 Aidan talk contribs created page SSTI (Redirected page to Skin and soft tissue infection) Tags: New redirect Visual edit
- 13:46, 25 July 2023 Aidan talk contribs created page Keytruda (Redirected page to Pembrolizumab) Tags: New redirect Visual edit
- 16:52, 24 July 2023 Aidan talk contribs deleted page Micrococcus species (content was: "#REDIRECT Micrococcus", and the only contributor was "Aidan" (talk))
- 12:04, 23 July 2023 Aidan talk contribs created page Borrelia miyamotoi (Created page with "{{DISPLAYTITLE:''Borrelia miyamotoi''}} == Background == * Tick-borne infection * Transmitted by hard-body ticks, including Vector::Ixodes scapularis (in northeastern and nortcentral North America), Vector::Ixodes pacificus (in northwestern North America), Vector::Ixodes ricinus (in Europe), Vector::Ixodes persulcatus (in Europe and Asia), and Vector::Ixodes ovatus, Vector::Ixodes nipponensis, and Vector::Ixodes pavoloskyi (in Asia) * Presen...") Tag: Visual edit
- 14:13, 20 July 2023 Aidan talk contribs created page Property:Cellular respiration (Created page with "Has type::text Allows value::aerobic Allows value::anaerobic Allows value::facultatively anaerobic")
- 14:11, 20 July 2023 Aidan talk contribs created page Anaerobic (Redirected page to Anaerobes) Tags: New redirect Visual edit
- 13:53, 19 July 2023 Aidan talk contribs created page Spontaneous gram-negative meningitis (Created page with "== Background == === Microbiology === * Most commonly caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter * Also Citrobacter, Serratia marcescens, Enterobacter, and Proteus mirabilis === Risk Factosr === * Diabetes mellitus * Cirrhosis * End-stage renal disease * Substance abuse, including alcohol use disorder * Cancer Category:CNS infections") Tag: Visual edit
- 13:48, 19 July 2023 Aidan talk contribs created page Gram-negative meningitis (Created page with "== Background == * Any bacterial meningitis involving gram-negative bacilli * Essentially three forms: ** Neonatal meningitis ** Healthcare-associated ventriculitis and meningitis ** Spontaneous gram-negative meningitis Category:CNS infections") Tag: Visual edit
- 17:31, 18 July 2023 Aidan talk contribs created page Atopobium rimae (Created page with "{{DISPLAYTITLE:''Atopobium rimae''}} * Stain::Gram-positive anaerobic Shape::bacillus * Previously known as Lactobacillus rimae * Most closely associated with odontogenic infections Category:Gram-positive bacilli Category:Anaerobes") Tag: Visual edit
- 13:50, 18 July 2023 Aidan talk contribs created page Infections associated with fish (Created page with "== Soft Tissue Infections == {| class="wikitable" !Organism !Micro !Distribution !Other Notes |- |Aeromonas |Gram-negative bacillus |Worldwide in warm fresh and brackish water |Often following alligator, fish, snake, or freshwater leech bites. Can also cause hemorrhagic diarrhea |- |Chromobacterium violaceum |Gram-negative bacillus with violet colonies |Soil and water in tropical and subtropical regions |Usually following laceration or bite with exposure to brack...") Tag: Visual edit
- 14:13, 17 July 2023 Aidan talk contribs created page Nivolumab (Created page with "* Immune checkpoint inhibitor targeting PD-1 * Indicated for melanoma, NSCLC, SCLC, RCC, Hodgkin lymphoma, head and neck squamous cell carcinoma, urothelial carcinoma, colorectal cancer, hepatocellular carcinoma, and esophageal squamous cell carcinoma * Not particularly immunosuppressive * May increase risk of routine bacterial infections (including C. difficile), fungal infections (aspergillosis, pneumocystis, candidemia), viral infections (V...") Tag: Visual edit
- 18:02, 13 July 2023 Aidan talk contribs created page Clubbing (Created page with "== Background == * Clinical exam finding of fingers and toes characterized in an increase in the mass of the distal fingertip and increase in the longitudinal and transverse nail plate curvature == Physical Examination == * Assess the thickness of the distal fingertip * Lovibond angle is over 180 degrees, compared to 160 degrees in normal nails * Schamroth sign == Etiologies == * Acquired, usually starting with thumb and index fingers ** Lung cancer, IPF, ...") Tag: Visual edit
- 20:20, 12 July 2023 Aidan talk contribs created page Cryopyrin-associated periodic syndrome (Created page with "== Background == * Mutation in NLRP3 gene * One of the periodic fever syndrome == Clinical Manifestations == * Three different clinical manifestations: ** Familial cold-associated syndrome (FCAS) *** Episodes of fever, rashes, arthralgias, usually triggered by exposure to cold ** Muckle-Wells syndrome (MWS) *** Episodes of fever, but with migrating urticaria-like lesions, ocular abnormalities, and progressive sensorineural deafness, and possibly amyloidosi...") Tag: Visual edit
- 20:12, 12 July 2023 Aidan talk contribs created page Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome (Created page with "== Background == * A cause of periodic fever syndrome that occurs mainly in young children * Rare in adults, though case reports exist == Clinical Manifestations == * Fever lasting 3 to 5 days, up to 40.5 degrees Celsius * Erythematous or exudative pharyngitis (90% of patients) * Cervical lymphadenopathy (75%) * Oral aphthosis (50%) * Possibly also headache, abdominal pain, nausea, vomiting, chills, malaise, myalgia, and arthralgia == Diagnostic Criteria == * Re...") Tag: Visual edit
- 20:09, 12 July 2023 Aidan talk contribs created page PFAPA (Redirected page to Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome) Tags: New redirect Visual edit
- 19:50, 12 July 2023 Aidan talk contribs created page Vagococcus fluvialis (Created page with "{{DISPLAYTITLE:''Vagococcus fluvialis''}} == Background == * Stain::Gram-positive Shape::coccus related to Enterococcus * Found in fish or animals, such as pigs, cattle, cats, and horses == Clinical Manifestations == * Skin and soft tissue infection, odontogenic infection, peritonitis, meningitis, bacteremia, and infective endocarditis == Management == * The ideal empiric treatment is unknown * May be susceptible to ampicillin, ceftraixone, TM...") Tag: Visual edit
- 14:45, 11 July 2023 Aidan talk contribs created page Schaalia (Created page with "* Genus of aerobic Stain::Gram-positive Shape::bacillus * Straight to slightly curved, may show branching * Previously included within the genus Actinomyces * Type species is Schaalia odontolytica, often referred to as Actinomyces odontolytica * Other species include Schaalia canis, Schaalia cardiffensis, Schaalia funkei, Schaalia georgiae, Schaalia hyovaginalis, Schaalia meyeri, Schaalia naturae, Schaalia radingae, S...") Tag: Visual edit
- 14:38, 11 July 2023 Aidan talk contribs created page Actinomyces neuii (Created page with "== Background == {{DISPLAYTITLE:''Actinomyces neuii''}} * Stain::Gram-positive Shape::bacillus in the genus Genus::Actinomyces * Rare cause of disease in humans == Further Reading == * Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium. ''Can J Infect Dis Med Microbiol''. 2016;2016:6017605. doi: [https://doi.org/10.1155/2016/6017605 10.1155/2016/6017605]. ** Review of 6 cases in Alberta from 2013-2014. Category:Gram...") Tag: Visual edit
- 16:53, 8 July 2023 Aidan talk contribs created page Tick bite prevention (Created page with "* Use DEET-containing topical '''insect repellent''' * Permethrin-treated clothing, shoes, and other gear * Routine '''tick checks''', ensuring examination around the ears, on the scalp, inside the belly button, in the armpits, around the waist, between the legs, and on the back of the knees * '''Bathing''' within 2 hours of coming indoors allows you to wash off ticks that haven't yet attached and also gives the opportunity for a tick check * Put dry clothes in the d...") Tag: Visual edit
- 16:38, 8 July 2023 Aidan talk contribs created page Tick removal (Created page with "* '''Step 1:''' Use fine-tipped tweezers to grasp the tick as close to the skin surface as possible. * '''Step 2:''' Pull up with steady, even pressure. Do not twist or jerk the tick. * '''Step 3:''' Clean the affected area with rubbing alcohol or soap and water. * DO NOT: ** Cover the tick with petroleum jelly, nail polish, soap, or other substances ** Burn the tick ** Squish the tick * If mouthparts are left behind, leave them alone; they will fall out on their own wit...") Tag: Visual edit
- 15:20, 22 June 2023 Aidan talk contribs created page Cutaneous spindle cell neoplasm (Created page with "{| class="wikitable" |+Differential diagnosis by architectural pattern !Pattern !Neosplasms |- |Fascicular pattern |Intradermal nodular fasciitis Acral fibromyxoma Pilar leiomyoma Leiomyosarcoma Angiosarcoma Atypical fibroxanthoma |- |Storiform/whorled pattern |Fibrous histiocytoma (dermatofibroma) Soft tissue perineurioma Dermatofibrosarcoma protuberans |- |Lobulated/plexiform pattern |Dermal nerve sheath myxoma Cellular neurothekeoma Plexiform schwannoma |- |Biphasic p...") Tag: Visual edit
- 17:39, 21 June 2023 Aidan talk contribs created page PNH (Created page with "#REDIRECT [Paroxysmal nocturnal hemoglobinuria] Category:Hematology")
- 17:04, 21 June 2023 Aidan talk contribs created page Tumor necrosis factor receptor-associated periodic syndrome (Created page with "==Background== * A periodic fever syndrome caused by autoimmunity * Autosomal dominant with incomplete penetrance * Rare, described in all ethnic groups * Usually presents in childhood, though 10% of cases are in those over age 30 years ==Clinical Manifestations== * Fever over 38 degrees over months to years in the absence of infection * Typically occur every five to six weeks, and last five days to 2 weeks or longer * Also: ** Myalgias and limb pain, sometimes migr...")
- 17:30, 20 June 2023 Aidan talk contribs created page Clavulin (Redirected page to Amoxicillin-clavulanic acid) Tags: New redirect Visual edit