Pseudomonas aeruginosa

From IDWiki
Pseudomonas aeruginosa

Background

Microbiology

  • Oxidase positive, non-fermenting Gram-negative bacillus

Mechanisms of Resistance

Epidemiology

  • Loves moist and wet environments
  • Causes healthcare-associated infections
    • UTI, SSI, bacteremia, HAP, VAP
    • Especially common in cystic fibrosis

Treatment

  • Refer to antipseudomonal antibiotics for specific treatment options
  • Preferred: piperacillin-tazobactam, ceftazidime, cefepime, aztreonam
    • If repeat testing confirms resistant to carbapenems but susceptibility to other β-lactams (which is most commonly caused by decreased OprD), use an extended infusion of a β-lactam
  • Alternatives: meropenem or imipenem
  • Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection

Multidrug-Resistant Isolates