Tigecycline
From IDWiki
Background
- Glycylcycline antibiotic
Spectrum of Activity
- Related to tetracycline and doxycycline, with expanded coverage to include streptococci and Enterobacteriaceae, but without coverage for unusual Gram-negative bacteria or Chlamydia trachomatis
- Does cover Acinetobacter and Stenotrophomonas
Pharmacokinetics and Pharmacodynamics
- Rapidly concentrates in tissue, but poor concentration in urine and lung tissue
Dosing
- Intraabdominal infection: 100 mg IV load followed by 50 mg IV q12h
- Pneumonia: 100 mg IV load followed by 50 mg IV q12h
- High dosing may be useful in HAP/VAP with 100 mg IV q12h
- Skin and soft tissue infection: 100 mg IV load followed by 50 mg IV q12h
Safety
- Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP
- Commonly causes nausea, vomiting, and diarrhea
- Also anemia, thrombocytopenia, hepatitis, jaundice, AKI
