Fluoroquinolones

Background

Pharmacokinetics and Pharmacodynamics

• Pharmacodynamics is best predicted by:
  • Gram-negative bacteria: concentration-dependent with AUC₂₄:MIC ≥125
  • Gram-positive bacteria: concentration-independent with AUC₂₄:MIC ≥30
  • Anaerobes: concentration-independent with AUC₂₄:MIC ~50

Antibiotics

• Ciprofloxacin
• Moxifloxacin
• Levofloxacin