Dosing
- Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily
- Intravenous:
- Usual dose: 1 g (1000 mg/ 200 mg) IV every 8 hours
- High dose: 2 g (2000 mg/ 200 mg) IV every 8 to 12 hours
Renal Dosing
| CrCl (mL/min) | Dose |
|---|---|
| Oral | |
| >30 | 875/125 mg p.o. q12h |
| 10-29 | 500/125 mg p.o. q12h |
| <10 | 500/125 mg p.o. q24h |
| Hemodialysis | 500/125 mg p.o. q24h (given after dialysis on dialysis days) |
| Peritoneal dialysis | 250/125 mg p.o. q12h |
| CRRT | Usual dose |
| Intravenous | |
| >30 | 1 g IV q8h |
| 10-29 | 1 g IV followed by 500 mg IV q12h |
| <10 | 1 g IV followed by 500 mg IV q24h |
| Hemodialysis | 1 g IV followed by 500 mg IV q24h (given after dialysis on dialysis days) |
