Thrombocytopenia: Difference between revisions

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See also Drug-induced thrombocytopenia

Differential Diagnosis

Pseudothrombocytopenia
Decreased production
- Viral infection
- Malignancy
Destruction/Consumption
- Immune-mediated thrombocytopenic purpura (ITP)
  - Primary ITP
  - Hepatitis C, HIV, and Helicobacter pylori; also CMV, EBV, VZV, Zika virus
  - Autoimmune: antiphospholipid syndrome, Evans syndrome, IBD, RA, SLE
  - CVID
  - CLL
  - Lymphoma
- Drug-induced thrombocytopenia: abciximab, beta-lactams (including penicillins and cephalosporins), carbamazepine, epifitabide, gold compounds, heparin, linezolid, MMR vaccine, phenytoin, piperacillin, quinidine, quinine, rifampin, sulfonamides (including TMP-SMX), valproic acid, and vancomycin
- Thrombotic microangiopathy
  - TTP/HUS, other TMAs
Sequestration
- Splenomegaly

Investigations

Rule out secondary causes with hepatitis C virus, HIV, and Helicobacter pylori serology

@@ Line 1: / Line 1: @@
+* See also [[Drug-induced thrombocytopenia]]
-== Differential Diagnosis ==
+==Differential Diagnosis==
-* Decreased production
-** Viral infections
-** Malignancies
-* Destruction/Consumptiom
-** Immune-mediated thrombocytopenic purpura (ITP)
-*** Hepatitis C, HIV, and ''H. pylori''
-** Thrombotic microangiopathy
-*** TTP/HUS, other TMAs
-* Sequestration
-** Splenomegaly
+*Pseudothrombocytopenia
-== Investigations ==
+*Decreased production
+**Viral infection
+**[[Malignancy]]
+*Destruction/Consumption
+**[[Immune-mediated thrombocytopenic purpura]] (ITP)
+***Primary ITP
+***[[Hepatitis C]], [[HIV]], and [[Helicobacter pylori]]; also [[CMV]], [[EBV]], [[VZV]], [[Zika virus]]
+***Autoimmune: [[antiphospholipid syndrome]], [[Evans syndrome]], [[IBD]], [[RA]], [[SLE]]
+***[[CVID]]
+***[[CLL]]
+***[[Lymphoma]]
+**[[Drug-induced thrombocytopenia]]: [[abciximab]], beta-lactams (including [[penicillins]] and [[cephalosporins]]), [[carbamazepine]], [[epifitabide]], gold compounds, [[Heparin-inducted thrombocytopenia|heparin]], [[linezolid]], [[MMR vaccine]], [[phenytoin]], [[piperacillin]], [[quinidine]], [[quinine]], [[rifampin]], sulfonamides (including [[TMP-SMX]]), [[valproic acid]], and [[vancomycin]]
+**[[Thrombotic microangiopathy]]
+***[[TTP]]/[[HUS]], other TMAs
+*Sequestration
+**[[Splenomegaly]]
+==Investigations==
-* Rule out secondary causes with HCV, HIV, and H. pylori serology
+*Rule out secondary causes with [[hepatitis C virus]], [[HIV]], and [[Helicobacter pylori]] serology
 [[Category:Hematology]]