Rifampin

• Inhibits bacterial DNA-dependent RNA polymerase
• Never given alone due to rapid resistance
• Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
• Avoid in liver failure

Dosing

• As adjunct to fluoroquinolone for Staphylococcus aureus:
  • Weight <60 kg: 600 mg p.o. daily
  • Weight >60 kg: 450 mg p.o. twice daily

Safety

Drug-Drug Interactions

• Multiple
• Other antibiotics include clindamycin, doxycycline, linezolid, moxifloxacin, trimethoprim, and fusidic acid