Drug-induced thrombocytopenia
From IDWiki
- Typical onset 5 to 10 days after drug administration
- Nadir of less than 20
- A severe form is heparin-induced thrombocytopenia, discussed elsewhere
- Counts usually start to recover after 4 or 5 half-lives of the offending medication
- IVIG can be given in severe thrombocytopenia
- Drugs associated with non-immune thrombocytopenia
- Impaired thrombopoiesis: chemotherapy, interferon-alpha, linezolid, botrezomib, thiazide diuretics, ethanol, tolbutamid, ganciclovir
- Platelet apoptosis: tamoxifen, navitoclax, methotrexate, nuclear factor-kB inhibitors, lovastatin, doxorubicin, bexarotene, arsenic trioxide, aspirin, vancomycin, trifluoperazine, balhimycin, carmustine, cisplatin
- Other drugs:
