Thrombotic microangiopathy

From IDWiki
Disease Clinical Clues
Primary
Thrombotic thrombocytopenia purpura PT/INR and PTT are normal
Hemolytic-uremic syndrome PT/INR and PTT are normal, severe AKI
Atypical hemolytic-uremic syndrome PT/INR and PTT are normal, severe AKI
HELLP syndrome pregnancy
Secondary
Autoimmune disease, including systemic lupus erythematosus or antiphospholid antibody syndrome
Drug-induced thrombotic microangiopathy including quinine, ticlopidine, and chemotherapy (mitomycin, gemcitabine, cyclosporine, and tacrolimus, though it may also be caused by the underlying condition
Sepsis
Secondary hemolytic-uremic syndrome most commonly from Streptococcus pneumoniae or influenza
DIC PT/INR and PTT are prolonged
Malignancy
HIV