Secondary hemolytic-uremic syndrome
From IDWiki
Background
- One of the thrombotic microangiopathies
- Different pathophysiology and treatment from typical hemolytic-uremic syndrome (after STEC diarrhea) and atypical hemolytic-uremic syndrome (though often grouped with aHUS)
- Associated with autoimmune diseases, transplantation, malignancy, infection, cytotoxic mediation, or pregnancy
- Most common associations are with Streptococcus pneumoniae and influenza
- Possibly acute Clostridioides difficile123
- Solid organ transplantation, mostly in the month or months after transplantation but rarely after a year4
- Hematopoietic stem cell transplantation, up to months to years after transplant
- Systemic lupus erythematosus5
- Multiple solid organ malignancies (usually metastatic) are associated with TMA, though prostate cancer (non-metastatic) appears to favour an HUS-like pattern6
- Normal pregnancy7
- Drug-induced thrombotic microangiopathy
References
- ^ Maryam Keshtkar-Jahromi, Mahsa Mohebtash. Hemolytic uremic syndrome andClostridium difficilecolitis. Journal of Community Hospital Internal Medicine Perspectives. 2012;2(3):19064. doi:10.3402/jchimp.v2i3.19064.
- ^ Qasim Khurshid, Anas Mahmoud, Maria Shahid, Alaa Mohamed, Amir Shahbaz. Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection. Cureus. 2020. doi:10.7759/cureus.9005.
- ^ Anthony S. Alvarado, Sergey V. Brodsky, Tibor Nadasdy, Neeraj Singh. Hemolytic uremic syndrome associated with Clostridium difficile infection. Clinical Nephrology. 2014;81(04):302-306. doi:10.5414/cn107691.
- ^ R.A. Caires, I.D.B. Marques, L.P. Repizo, V.A.H. Sato, L.P.F. Carmo, D.J.B. Machado, F.J. de Paula, W.C. Nahas, E. David-Neto. De Novo Thrombotic Microangiopathy After Kidney Transplantation: Clinical Features, Treatment, and Long-Term Patient and Graft Survival. Transplantation Proceedings. 2012;44(8):2388-2390. doi:10.1016/j.transproceed.2012.07.039.
- ^ M.D. Hughson, T. Nadasdy, G.A. McCarty, C. Sholer, K-W. Min, F. Silva. Renal Thrombotic Microangiopathy in Patients With Systemic Lupus Erythematosus and the Antiphospholipid Syndrome. American Journal of Kidney Diseases. 1992;20(2):150-158. doi:10.1016/s0272-6386(12)80543-9.
- ^ Klaus Lechner, Hanna Lena Obermeier. Cancer-Related Microangiopathic Hemolytic Anemia. Medicine. 2012;91(4):195-205. doi:10.1097/md.0b013e3182603598.
- ^ M Egbor, A Johnson, F Harris, D Makanjoula, H Shehata. Pregnancy-associated atypical haemolytic uraemic syndrome in the postpartum period: a case report and review of the literature. Obstetric Medicine. 2011;4(2):83-85. doi:10.1258/om.2011.100059.
