Drug-induced thrombotic microangiopathy

Background

• A thrombotic microangiopathy caused by exposure to certain medications
• May present with a TTP- or HUS-like syndrome
• Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic
• Associations that are probably true include: bevacizumab, cocaine, cyclosporine, docetaxel, everolimus, gemcitabine, interferon α, interferon β, interferon polycarboxylate, mitomycin, muromonab-CD3, oxaliplatin, penicillin, pentostatin, quetiapine, quinine, sirolimus, sulfisoxazole, sunitinib, tacrolimus, trielina, and vincristine

Further Reading

• Drug-induced thrombotic microangiopathy: a systematic review of published reports. Blood. 2015 Jan 22;125(4):616-8. doi: 10.1182/blood-2014-11-611335. PMID: 25414441; PMCID: PMC4304106.