Thrombocytopenia: Difference between revisions
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| − | == |
+ | ==Differential Diagnosis== |
| + | *Pseudothrombocytopenia |
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| − | * |
+ | *Decreased production |
| − | ** |
+ | **Viral infection |
| − | ** Malignancies |
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| + | **[[Malignancy]] |
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| − | * |
+ | *Destruction/Consumption |
| − | ** |
+ | **[[Immune-mediated thrombocytopenic purpura]] (ITP) |
| − | *** Hepatitis C, HIV, and ''H. pylori'' |
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| + | ***Primary ITP |
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| ⚫ | |||
| + | ***[[Hepatitis C]], [[HIV]], and [[Helicobacter pylori]]; also [[CMV]], [[EBV]], [[VZV]], [[Zika virus]] |
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| ⚫ | |||
| + | ***Medications: [[abciximab]], beta-lactams (including [[penicillins]] and [[cephalosporins]]), [[carbamazepine]], [[epifitabide]], gold compounds, [[Heparin-inducted thrombocytopenia|heparin]], [[linezolid]], [[MMR vaccine]], [[phenytoin]], [[piperacillin]], [[quinidine]], [[quinine]], [[rifampin]], sulfonamides (including [[TMP-SMX]]), [[valproic acid]], and [[vancomycin]] |
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| ⚫ | |||
| + | ***Autoimmune: [[antiphospholipid syndrome]], [[Evans syndrome]], [[IBD]], [[RA]], [[SLE]] |
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| ⚫ | |||
| + | ***[[CVID]] |
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| + | ***[[CLL]] |
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| + | ***[[Lymphoma]] |
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| ⚫ | |||
| ⚫ | |||
| ⚫ | |||
| ⚫ | |||
| − | == |
+ | ==Investigations== |
| − | * |
+ | *Rule out secondary causes with [[hepatitis C virus]], [[HIV]], and [[Helicobacter pylori]] serology |
[[Category:Hematology]] |
[[Category:Hematology]] |
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Latest revision as of 13:01, 25 March 2024
Differential Diagnosis
- Pseudothrombocytopenia
- Decreased production
- Viral infection
- Malignancy
- Destruction/Consumption
- Immune-mediated thrombocytopenic purpura (ITP)
- Primary ITP
- Hepatitis C, HIV, and Helicobacter pylori; also CMV, EBV, VZV, Zika virus
- Medications: abciximab, beta-lactams (including penicillins and cephalosporins), carbamazepine, epifitabide, gold compounds, heparin, linezolid, MMR vaccine, phenytoin, piperacillin, quinidine, quinine, rifampin, sulfonamides (including TMP-SMX), valproic acid, and vancomycin
- Autoimmune: antiphospholipid syndrome, Evans syndrome, IBD, RA, SLE
- CVID
- CLL
- Lymphoma
- Thrombotic microangiopathy
- Immune-mediated thrombocytopenic purpura (ITP)
- Sequestration
Investigations
- Rule out secondary causes with hepatitis C virus, HIV, and Helicobacter pylori serology
