Secondary hemolytic-uremic syndrome
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Revision as of 13:53, 20 April 2023 by Aidan (talk | contribs) (Created page with " ==Background== *One of the thrombotic microangiopathies *Different pathophysiology and treatment from typical hemolytic-uremic syndrome (after STEC diarrhea) and atypical hemolytic-uremic syndrome (though often grouped with aHUS) *Associated with autoimmune diseases, transplantation, malignancy, infection, cytotoxic mediation, or pregnancy **Most common associations are with Streptococcus pneumoniae an...")
Background
- One of the thrombotic microangiopathies
- Different pathophysiology and treatment from typical hemolytic-uremic syndrome (after STEC diarrhea) and atypical hemolytic-uremic syndrome (though often grouped with aHUS)
- Associated with autoimmune diseases, transplantation, malignancy, infection, cytotoxic mediation, or pregnancy
- Most common associations are with Streptococcus pneumoniae and influenza
- Solid organ transplantation, mostly in the month or months after transplantation but rarely after a year[1]
- Hematopoietic stem cell transplantation, up to months to years after transplant
- Systemic lupus erythematosus[2]
- Multiple solid organ malignancies (usually metastatic) are associated with TMA, though prostate cancer (non-metastatic) appears to favour an HUS-like pattern[3]
- Normal pregnancy[4]
- Drug-induced thrombotic microangiopathy
- ↑ Caires RA, Marques ID, Repizo LP, Sato VA, Carmo LP, Machado DJ, de Paula FJ, Nahas WC, David-Neto E. De novo thrombotic microangiopathy after kidney transplantation: clinical features, treatment, and long-term patient and graft survival. Transplant Proc. 2012 Oct;44(8):2388-90. doi: 10.1016/j.transproceed.2012.07.039. PMID: 23026601.
- ↑ Hughson MD, Nadasdy T, McCarty GA, Sholer C, Min KW, Silva F. Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Kidney Dis. 1992 Aug;20(2):150-8. doi: 10.1016/s0272-6386(12)80543-9. PMID: 1496968.
- ↑ Lechner K, Obermeier HL. Cancer-related microangiopathic hemolytic anemia: clinical and laboratory features in 168 reported cases. Medicine (Baltimore). 2012 Jul;91(4):195-205. doi: 10.1097/MD.0b013e3182603598. PMID: 22732949.
- ↑ Egbor M, Johnson A, Harris F, Makanjoula D, Shehata H. Pregnancy-associated atypical haemolytic uraemic syndrome in the postpartum period: a case report and review of the literature. Obstet Med. 2011 Jun;4(2):83-5. doi: 10.1258/om.2011.100059. Epub 2011 Jun 9. PMID: 27582861; PMCID: PMC4989735.
References
- ^ Qasim Khurshid, Anas Mahmoud, Maria Shahid, Alaa Mohamed, Amir Shahbaz. Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection. Cureus. 2020. doi:10.7759/cureus.9005.
- ^ Anthony S. Alvarado, Sergey V. Brodsky, Tibor Nadasdy, Neeraj Singh. Hemolytic uremic syndrome associated with Clostridium difficile infection. Clinical Nephrology. 2014;81(04):302-306. doi:10.5414/cn107691.
- ^ R.A. Caires, I.D.B. Marques, L.P. Repizo, V.A.H. Sato, L.P.F. Carmo, D.J.B. Machado, F.J. de Paula, W.C. Nahas, E. David-Neto. De Novo Thrombotic Microangiopathy After Kidney Transplantation: Clinical Features, Treatment, and Long-Term Patient and Graft Survival. Transplantation Proceedings. 2012;44(8):2388-2390. doi:10.1016/j.transproceed.2012.07.039.
- ^ M.D. Hughson, T. Nadasdy, G.A. McCarty, C. Sholer, K-W. Min, F. Silva. Renal Thrombotic Microangiopathy in Patients With Systemic Lupus Erythematosus and the Antiphospholipid Syndrome. American Journal of Kidney Diseases. 1992;20(2):150-158. doi:10.1016/s0272-6386(12)80543-9.
- ^ Klaus Lechner, Hanna Lena Obermeier. Cancer-Related Microangiopathic Hemolytic Anemia. Medicine. 2012;91(4):195-205. doi:10.1097/md.0b013e3182603598.
- ^ M Egbor, A Johnson, F Harris, D Makanjoula, H Shehata. Pregnancy-associated atypical haemolytic uraemic syndrome in the postpartum period: a case report and review of the literature. Obstetric Medicine. 2011;4(2):83-85. doi:10.1258/om.2011.100059.
