Thrombotic microangiopathy
From IDWiki
- Syndrome of microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis leading to organ dysfunction
| Disease | Clinical Clues |
|---|---|
| Primary | |
| Thrombotic thrombocytopenia purpura | PT/INR and PTT are normal |
| Hemolytic-uremic syndrome | PT/INR and PTT are normal, severe AKI |
| Atypical hemolytic-uremic syndrome | PT/INR and PTT are normal, severe AKI |
| HELLP syndrome | pregnancy |
| Secondary | |
| Autoimmune disease, including systemic lupus erythematosus or antiphospholid antibody syndrome | |
| Drug-induced thrombotic microangiopathy | including quinine, ticlopidine, and chemotherapy (mitomycin, gemcitabine, cyclosporine, and tacrolimus, though it may also be caused by the underlying condition |
| Sepsis | |
| Secondary hemolytic-uremic syndrome | most commonly from Streptococcus pneumoniae or influenza |
| DIC | PT/INR and PTT are prolonged |
| Malignancy | |
| HIV | |
