Drug-induced neutropenia: Difference between revisions
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* [[Neutropenia]] caused by medications or recreational drugs |
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* Agranulocytosis refers to the complete absence of neutrophils or granulocytes (ANC of 0) |
* Agranulocytosis refers to the complete absence of neutrophils or granulocytes (ANC of 0) |
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| rowspan="7" |Antibiotics |
| rowspan="7" |Antibiotics |
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|Semisynthetic penicillins (amoxicillin, ampicillin) |
|Semisynthetic penicillins ([[amoxicillin]], [[ampicillin]]) |
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|Moderate |
|Moderate |
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|Both |
|Both |
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|- |
|- |
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|Cephalosporins |
|[[Cephalosporins]] |
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|Moderate |
|Moderate |
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|Both |
|Both |
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|- |
|- |
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|Vancomycin |
|[[Vancomycin]] |
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|High |
|High |
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|Both |
|Both |
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|- |
|- |
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|Macrolides |
|[[Macrolides]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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|TMP-SMX |
|[[TMP-SMX]] |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Dapsone |
|[[Dapsone]] |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Chloramphenicol |
|[[Chloramphenicol]] |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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| rowspan="2" |Antifungals |
| rowspan="2" |Antifungals |
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|Amphotericin |
|[[Amphotericin]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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|Flucytosine |
|[[Flucytosine]] |
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|Low |
|Low |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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| rowspan="2" |Antimalarials |
| rowspan="2" |Antimalarials |
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|Chloroquine |
|[[Chloroquine]] |
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|Low |
|Low |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Quinine |
|[[Quinine]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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| rowspan="4" |Antiinflammatory agents |
| rowspan="4" |Antiinflammatory agents |
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|Ibuprofen |
|[[Ibuprofen]] |
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|Low |
|Low |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Diclofenac |
|[[Diclofenac]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Sulfasalazine |
|[[Sulfasalazine]] |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Gold salts |
|[[Gold salts]] |
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| |
| |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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| rowspan="2" |Antithyroid drugs |
| rowspan="2" |Antithyroid drugs |
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|Methimazole |
|[[Methimazole]] |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Propylthiouracil |
|[[Propylthiouracil]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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| rowspan="3" |Psychotropic agents |
| rowspan="3" |Psychotropic agents |
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|Clozapine |
|[[Clozapine]] |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Phenothiazines (chlorpromazine) |
|Phenothiazines ([[chlorpromazine]]) |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Tricyclic agents (amitriptyline) |
|Tricyclic agents ([[amitriptyline]]) |
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|Low |
|Low |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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| rowspan="4" |Antiepileptics |
| rowspan="4" |Antiepileptics |
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|Carbamazepine |
|[[Carbamazepine]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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|Phenytoin |
|[[Phenytoin]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Valproate |
|[[Valproate]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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|Ethosuximide |
|[[Ethosuximide]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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| rowspan="5" |Cardiovascular drugs |
| rowspan="5" |Cardiovascular drugs |
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|Antiarrhythmic agents (procainamide, flecainide) |
|Antiarrhythmic agents ([[procainamide]], [[flecainide]]) |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|ACE inhibitors |
|[[ACE inhibitors]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Propranolol |
|[[Propranolol]] |
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|Low |
|Low |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Digoxin |
|[[Digoxin]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Ticlopidine |
|[[Ticlopidine]] |
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|High |
|High |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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| rowspan="4" |Diuretics |
| rowspan="4" |Diuretics |
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|Thiazides |
|[[Thiazides]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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|Furosemide |
|[[Furosemide]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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|Spironolactone |
|[[Spironolactone]] |
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|Low |
|Low |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Acetazolamide |
|[[Acetazolamide]] |
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|Low |
|Low |
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|Neutropenia |
|Neutropenia |
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|- |
|- |
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| rowspan="3" |Other |
| rowspan="3" |Other |
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|Deferiprone |
|[[Deferiprone]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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|- |
|- |
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|Levamisole |
|[[Levamisole]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
||
|- |
|- |
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|Rituximab |
|[[Rituximab]] |
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|Moderate |
|Moderate |
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|Agranulocytosis |
|Agranulocytosis |
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Revision as of 14:49, 27 February 2024
- Neutropenia caused by medications or recreational drugs
- Agranulocytosis refers to the complete absence of neutrophils or granulocytes (ANC of 0)
| Class | Drug | Frequency reported | Nature of reaction |
|---|---|---|---|
| Antibiotics | Semisynthetic penicillins (amoxicillin, ampicillin) | Moderate | Both |
| Cephalosporins | Moderate | Both | |
| Vancomycin | High | Both | |
| Macrolides | Low | Neutropenia | |
| TMP-SMX | High | Agranulocytosis | |
| Dapsone | High | Agranulocytosis | |
| Chloramphenicol | High | Agranulocytosis | |
| Antifungals | Amphotericin | Low | Neutropenia |
| Flucytosine | Low | Agranulocytosis | |
| Antimalarials | Chloroquine | Low | Agranulocytosis |
| Quinine | Moderate | Agranulocytosis | |
| Antiinflammatory agents | Ibuprofen | Low | Agranulocytosis |
| Diclofenac | Moderate | Agranulocytosis | |
| Sulfasalazine | High | Agranulocytosis | |
| Gold salts | Agranulocytosis | ||
| Antithyroid drugs | Methimazole | High | Agranulocytosis |
| Propylthiouracil | Moderate | Agranulocytosis | |
| Psychotropic agents | Clozapine | High | Agranulocytosis |
| Phenothiazines (chlorpromazine) | Moderate | Agranulocytosis | |
| Tricyclic agents (amitriptyline) | Low | Agranulocytosis | |
| Antiepileptics | Carbamazepine | Low | Neutropenia |
| Phenytoin | Moderate | Agranulocytosis | |
| Valproate | Low | Neutropenia | |
| Ethosuximide | Low | Neutropenia | |
| Cardiovascular drugs | Antiarrhythmic agents (procainamide, flecainide) | High | Agranulocytosis |
| ACE inhibitors | Moderate | Agranulocytosis | |
| Propranolol | Low | Agranulocytosis | |
| Digoxin | Moderate | Agranulocytosis | |
| Ticlopidine | High | Agranulocytosis | |
| Diuretics | Thiazides | Low | Neutropenia |
| Furosemide | Low | Neutropenia | |
| Spironolactone | Low | Agranulocytosis | |
| Acetazolamide | Low | Neutropenia | |
| Other | Deferiprone | Moderate | Agranulocytosis |
| Levamisole | Moderate | Agranulocytosis | |
| Rituximab | Moderate | Agranulocytosis |
- From [1]
- ↑ Christopher Gibson, Nancy Berliner; How we evaluate and treat neutropenia in adults. Blood 2014; 124 (8): 1251–1258. doi: https://doi.org/10.1182/blood-2014-02-482612
References
- ^ Christopher Gibson, Nancy Berliner. How we evaluate and treat neutropenia in adults. Blood. 2014;124(8):1251-1258. doi:10.1182/blood-2014-02-482612.
