Dapsone

From IDWiki

Background

  • Diamino-diphenyl sulfone

Indications

Dosing

  • Dermatitis herpetiformis
    • Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose
    • Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days
    • After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks
  • Pneumocystis prophylaxis (primary or secondary)
    • 100 mg PO once daily or in 2 divided doses as monotherapy
    • Continue until CD4 count >200 cells/mm3 for >3 months
  • Pneumocystis treatment: 100 mg PO once daily in combination with trimethoprim for 21 days

Safety

  • Check CBC, liver, and G6PD deficiency before starting