Dapsone
From IDWiki
Background
- Diamino-diphenyl sulfone
Indications
- Second-line Pneumocystis jirovecii prophylaxis (CD4 <200)
- Along with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae
Dosing
- Dermatitis herpetiformis
- Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose
- Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days
- After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks
- Pneumocystis prophylaxis (primary or secondary)
- 100 mg PO once daily or in 2 divided doses as monotherapy
- Continue until CD4 count >200 cells/mm3 for >3 months
- Pneumocystis treatment: 100 mg PO once daily in combination with trimethoprim for 21 days
Safety
- Check CBC, liver, and G6PD deficiency before starting
