Digoxin

Drug-Drug Interactions

• Major interaction with amiodarone

Metabolism

• Digoxin is a s a substrate of P-gp efflux transporter
  • Other substrates include digoxin, simvastatin, cyclosporine, and colchicine
  • It is inhibited by amiodarone, dabigatran, verapamil, macrolides, grapefruit