Drug-drug interactions: Difference between revisions

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|CYP1A2
|CYP1A2
|[[amiodarone]]<br />[[cimetidine]]<br />'''[[ciprofloxacin]]'''
|[[amiodarone]]<br />[[cimetidine]]<br />'''[[ciprofloxacin]]'''
|[[fluvoxamine]]<br />'''[[interferon]]'''<br />methoxsalen
|[[fluvoxamine]]<br />'''[[interferon]]'''<br />[[methoxsalen]]
|[[Nicotine use disorder|cigarette smoking]]<br />[[Cannabis use disorder|marijuana smoking]]<br />[[modafinil]]<br />'''[[nafcillin]]'''
|[[Nicotine use disorder|cigarette smoking]]<br />[[Cannabis use disorder|marijuana smoking]]<br />[[modafinil]]<br />'''[[nafcillin]]'''
|[[amitriptyline]]<br />[[caffeine]]<br />[[clomipramine]]<br />[[clozapine]]<br />[[cyclobenzaprine]]<br />[[estradiol]]<br />[[fluvoxamine]]
|[[amitriptyline]]<br />[[caffeine]]<br />[[clomipramine]]<br />[[clozapine]]<br />[[cyclobenzaprine]]<br />[[estradiol]]<br />[[fluvoxamine]]<br />[[haloperidol]]
|[[mexiletine]]<br />[[naproxen]]<br />[[olanzapine]]<br />[[ondansetron]]<br />[[phenacetine]]<br />[[propranolol]]<br />[[riluzole]]<br />[[ropivacaine]]
[[haloperidol]]
⚫
|[[tacrine]]<br />[[theophylline]]<br />[[tizanidine]]<br />[[verapamil]]<br />[[Warfarin|R-warfarin]]<br />[[zileuton]]<br />[[zolmitriptan]]
⚫
|mexiletine<br />[[naproxen]]<br />[[olanzapine]]

[[ondansetron]]

phenacetine<br />[[propranolol]]<br />riluzole

ropivacaine
⚫
|tacrine<br />[[theophylline]]<br />[[tizanidine]]<br />[[verapamil]]<br />R-[[warfarin]]<br />zileuton<br />[[zolmitriptan]]
|-
|-
!CYP
!CYP
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|-
|-
|CYP2B6
|CYP2B6
|ticlopidine
|[[ticlopidine]]
|thiotepa
|[[thiotepa]]
|[[phenobarbital]]<br />'''[[rifampin]]'''
|[[phenobarbital]]<br />'''[[rifampin]]'''
|[[bupropion]]<br />[[cyclophosphamide]]
|[[bupropion]]<br />[[cyclophosphamide]]
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|CYP2C8
|CYP2C8
|[[gemfibrozil]]<br />[[montelukast]]<br />[[pioglitazone]]
|[[gemfibrozil]]<br />[[montelukast]]<br />[[pioglitazone]]
|quercetin<br />[[rosiglitazone]]<br />'''[[trimethoprim]]'''
|[[quercetin]]<br />[[rosiglitazone]]<br />'''[[trimethoprim]]'''
|'''[[rifampin]]'''
|'''[[rifampin]]'''
|amodiaquine<br />'''[[dasabuvir]]'''
|[[amodiaquine]]<br />'''[[dasabuvir]]'''
|cerivastatin<br />[[paclitaxel]]
|[[cerivastatin]]<br />[[paclitaxel]]
|torsemide<br />[[repaglinide]]
|[[torsemide]]<br />[[repaglinide]]
|-
|-
!CYP
!CYP
Line 53: Line 46:
|CYP2C9
|CYP2C9
|[[amiodarone]]<br />[[fenofibrate]]<br />'''[[fluconazole]]'''<br />[[fluvastatin]]<br />[[fluvoxamine]]<br />'''[[isoniazid]]'''
|[[amiodarone]]<br />[[fenofibrate]]<br />'''[[fluconazole]]'''<br />[[fluvastatin]]<br />[[fluvoxamine]]<br />'''[[isoniazid]]'''
|[[probenecid]]<br />[[sertraline]]<br />'''[[sulfamethoxazole]]'''<br />teniposide<br />'''[[voriconazole]]'''<br />zafirlukast
|[[probenecid]]<br />[[sertraline]]<br />'''[[sulfamethoxazole]]'''<br />[[teniposide]]<br />'''[[voriconazole]]'''<br />[[zafirlukast]]
|'''[[rifampin]]'''<br />secorbarbital
|'''[[rifampin]]'''<br />[[secorbarbital]]
|[[amitriptyline]]<br />[[celecoxib]]<br />[[diclofenac]]<br />[[fluoxetine]]<br />[[fluvastatin]]
|[[amitriptyline]]<br />[[celecoxib]]<br />[[diclofenac]]<br />[[fluoxetine]]<br />[[fluvastatin]]<br />[[glipizide]]<br />[[glyburide]]<br />[[ibuprofen]]
⚫
|[[irbesartan]]<br />[[lornoxicam]]<br />[[losartan]]<br />[[meloxicam]]<br />[[nateglinide]]<br />[[omeprazole]]<br />[[phenytoin]]
[[glipizide]]<br />[[glyburide]]
⚫
|[[piroxicam]]<br />[[rosiglitazone]]<br />[[rosuvastatin]]<br />[[Warfarin|S-warfarin]]<br />[[tamoxifen]]<br />[[tolbutamide]]<br />[[torsemide]]

[[ibuprofen]]
|[[irbesartan]]<br />lornoxicam<br />[[losartan]]
⚫
[[meloxicam]]<br />nateglinide<br />[[omeprazole]]<br />[[phenytoin]]
⚫
|piroxicam<br />[[rosiglitazone]]<br />[[rosuvastatin]]<br />S-[[warfarin]]<br />tamoxifen<br />tolbutamide<br />torsemide
|-
|-
!CYP
!CYP
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|-
|-
|CYP2C19
|CYP2C19
|[[cimetidine]]<br />[[esomeprazole]]<br />felbamate<br />[[fluoxetine]]<br />fluvoxamine<br />[[indomethacin]]<br />'''[[ketoconazole]]'''<br />[[lansoprazole]]
|[[cimetidine]]<br />[[esomeprazole]]<br />[[felbamate]]<br />[[fluoxetine]]<br />[[fluvoxamine]]<br />[[indomethacin]]<br />'''[[ketoconazole]]'''<br />[[lansoprazole]]
|[[modafinil]]<br />[[omeprazole]]<br />oxcarbazepine<br />[[pantoprazole]]<br />[[probenecid]]<br />[[rabeprazole]]<br />ticlopidine<br />[[topiramate]]
|[[modafinil]]<br />[[omeprazole]]<br />[[oxcarbazepine]]<br />[[pantoprazole]]<br />[[probenecid]]<br />[[rabeprazole]]<br />[[ticlopidine]]<br />[[topiramate]]
|[[carbamazepine]]<br />norethindrone<br />prednisone<br />'''[[rifampin]]'''
|[[carbamazepine]]<br />[[norethindrone]]<br />[[prednisone]]<br />'''[[rifampin]]'''
|carisoprodol<br />'''[[chloramphenicol]]'''<br />[[citalopram]]<br />clomipramine<br />cyclophosphamide<br />esomeprazole<br />hexobarbital
|[[carisoprodol]]<br />'''[[chloramphenicol]]'''<br />[[citalopram]]<br />[[clomipramine]]<br />[[cyclophosphamide]]<br />[[esomeprazole]]<br />[[hexobarbital]]<br />[[indomethacin]]
|[[lansoprazole]]<br />[[moclobemide]]<br />'''[[nelfinavir]]'''<br />[[nilutamide]]<br />[[omeprazole]]<br />[[pantoprazole]]<br />[[phenobarbital]]<br />[[phenytoin]]
indomethacin
|[[lansoprazole]]<br />moclobemide<br />'''[[nelfinavir]]'''<br />nilutamide
|[[primidone]]<br />[[progesterone]]<br />'''[[proguanil]]'''<br />[[propranolol]]<br />[[rabeprazole]]<br />[[teniposide]]<br />'''[[voriconazole]]'''
[[omeprazole]]<br />[[pantoprazole]]<br />[[phenobarbital]]

[[phenytoin]]
|primidone<br />[[progesterone]]<br />'''[[proguanil]]'''<br />[[propranolol]]<br />[[rabeprazole]]<br />teniposide<br />'''[[voriconazole]]'''
|-
|-
!CYP
!CYP
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|-
|-
|CYP2D6
|CYP2D6
|amiodarone<br />bupropion<br />celecoxib<br />chlorpheniramine<br />chlorpromazine<br />cimetidine<br />citalopram<br />clemastine<br />clomipramine<br />cocaine<br />diphenhydramine<br />doxepin<br />doxorubicin<br />duloxetine
|[[amiodarone]]<br />[[bupropion]]<br />[[celecoxib]]<br />[[chlorpheniramine]]<br />[[chlorpromazine]]<br />[[cimetidine]]<br />[[citalopram]]<br />[[clemastine]]<br />[[clomipramine]]<br />[[cocaine]]<br />[[diphenhydramine]]<br />[[doxepin]]<br />[[doxorubicin]]<br />[[duloxetine]]<br />[[escitalopram]]
⚫
|[[fluoxetine]]<br />[[hydroxyzine]]<br />[[metoclopramide]]<br />[[mibefradil]]<br />[[midodrine]]<br />[[moclobemide]]<br />[[paroxetine]]<br />[[perphenazine]]<br />[[quinidine]]<br />[[ranitidine]]<br />'''[[ritonavir]]'''<br />[[sertraline]]<br />[[terbinafine]]<br />[[ticlopidine]]
escitalopram
⚫
|[[dexamethasone]]<br />'''[[rifampin]]'''
⚫
|fluoxetine<br />hydroxyzine<br />metoclopramide<br />mibefradil<br />midodrine<br />moclobemide<br />paroxetine<br />perphenazine<br />quinidine<br />ranitidine<br />'''[[ritonavir]]'''<br />sertraline<br />terbinafine<br />ticlopidine
|[[alprenolol]]<br />[[amitriptyline]]<br />[[amphetamine]]<br />[[aripiprazole]]<br />[[atomoxetine]]<br />[[carvedilol]]<br />[[chlorpheniramine]]<br />[[chlorpromazine]]<br />[[clomipramine]]<br />[[codeine]]
⚫
|dexamethasone<br />'''[[rifampin]]'''
|alprenolol<br />amitriptyline<br />amphetamine<br />aripiprazole<br />atomoxetine<br />carvedilol<br />chlorpheniramine<br />chlorpromazine<br />clomipramine<br />codeine
|[[debrisoquine]]<br />[[desipramine]]<br />[[dexfenfluramine]]<br />[[dextromethorphan]]<br />[[duloxetine]]<br />[[encainide]]<br />[[flecainide]]<br />[[fluoxetine]]<br />[[fluvoxamine]]<br />[[haloperidol]]
⚫
|[[imipramine]]<br />[[lidocaine]]<br />[[methoxyamphetamine]]<br />[[metoclopramide]]<br />[[paroxetine]]<br />[[perphenazine]]<br />[[propafenone]]<br />[[Metoprolol|S-metoprolol]]<br />[[thioridazine]]<br />[[timolol]]
|debrisoquine
desipramine<br />dexfenfluramine<br />dextromethorphan<br />duloxetine

encainide

flecainide<br />fluoxetine<br />fluvoxamine<br />haloperidol
⚫
|imipramine<br />lidocaine<br />methoxyamphetamine<br />metoclopramide<br />paroxetine<br />perphenazine<br />propafenone<br />S-metoprolol<br />thioridazine<br />timolol
|-
|-
!CYP
!CYP
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|-
|-
|CYP2E1
|CYP2E1
| colspan="2" |disulfiram
|[[disulfiram]]
|
|ethanol<br />'''[[isoniazid]]'''
|[[Alcohol use disorder|ethanol]]<br />'''[[isoniazid]]'''
|acetaminophen<br />chlorzoxazone<br />enflurane
|ethanol<br />halothane<br />isoflurane
|[[acetaminophen]]<br />[[chlorzoxazone]]<br />[[enflurane]]
⚫
|[[ethanol]]<br />[[halothane]]<br />[[isoflurane]]
|methoxyflurane<br />sevoflurane
|[[methoxyflurane]]<br />[[sevoflurane]]
|-
|-
!CYP
!CYP
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|-
|-
|CYP3A
|CYP3A
|amiodarone<br />aprepitant<br />cimetidine<br />'''[[clarithromycin]]'''<br />'''[[cobicistat]]'''<br />'''[[delavirdine]]'''<br />diltiazem<br />'''[[elvitegravir]]'''<br />'''[[erythromycin]]'''<br />'''[[fluconazole]]'''<br />fluvoxamine<br />gestodene<br />imatinib
|[[amiodarone]]<br />[[aprepitant]]<br />[[cimetidine]]<br />'''[[clarithromycin]]'''<br />'''[[cobicistat]]'''<br />'''[[delavirdine]]'''<br />[[diltiazem]]<br />'''[[elvitegravir]]'''<br />'''[[erythromycin]]'''<br />'''[[fluconazole]]'''<br />[[fluvoxamine]]<br />[[gestodene]]<br />[[imatinib]]<br />'''[[indinavir]]'''
|'''[[isavuconazonium]]'''<br />'''[[itraconazole]]'''<br />'''[[ketoconazole]]'''<br />[[mibefradil]]<br />[[mifepristone]]<br />[[nefazodone]]<br />'''[[nelfinavir]]'''<br />[[norfluoxetine]]<br />'''[[posaconazole]]'''<br />'''[[ritonavir]]'''<br />'''[[saquinavir]]'''<br />[[verapamil]]<br />'''[[voriconazole]]'''
'''[[indinavir]]'''
|'''[[isavuconazonium]]'''<br />'''[[itraconazole]]'''<br />'''[[ketoconazole]]'''<br />mibefradil<br />mifepristone<br />nefazodone<br />'''[[nelfinavir]]'''<br />norfluoxetine<br />'''[[posaconazole]]'''<br />'''[[ritonavir]]'''<br />'''[[saquinavir]]'''<br />verapamil<br />'''[[voriconazole]]'''
|[[barbiturates]]<br />[[carbamazepine]]<br />'''[[efavirenz]]'''<br />[[glucocorticoids]]<br />[[modafinil]]<br />[[nevirapine]]<br />[[oxcarbazepine]]<br />[[phenobarbital]]<br />[[phenytoin]]<br />[[pioglitazone]]<br />'''[[rifabutin]]'''<br />'''[[rifampin]]'''<br />[[St. John's wort]]
|[[alfentanil]]<br />[[alprazolam]]<br />[[amlodipine]]<br />[[aprepitant]]<br />[[aripiprazole]]<br />'''[[artemisinin]]'''<br />[[astemizole]]<br />'''[[atazanavir]]'''<br />[[atorvastatin]]<br />'''[[bedaquiline]]'''<br />[[buspirone]]<br />[[cafergot]]<br />[[chlorpheniramine]]<br />[[cilostazol]]<br />'''[[clarithromycin]]'''<br />[[cocaine]]<br />[[cyclosporine]]<br />'''[[daclatasvir]]'''<br />'''[[dapsone]]'''<br />'''[[darunavir]]'''<br />[[dexamethasone]]<br />[[dextromethorphan]]<br />[[diltiazem]]<br />[[docetaxel]]<br />[[domperidone]]<br />'''[[elbasvir]]'''<br />[[eplerenone]]
|barbiturates<br />carbamazepine<br />'''[[efavirenz]]'''<br />glucocorticoids<br />modafinil<br />nevirapine<br />oxcarbazepine<br />phenobarbital<br />phenytoin<br />pioglitazone<br />'''[[rifabutin]]'''<br />'''[[rifampin]]'''<br />St. John’s wort
|alfentanil<br />alprazolam<br />amlodipine<br />aprepitant<br />aripiprazole<br />'''[[artemisinin]]'''<br />astemizole<br />'''[[atazanavir]]'''<br />atorvastatin<br />'''[[bedaquiline]]'''<br />buspirone<br />cafergot<br />chlorpheniramine<br />cilostazol<br />'''[[clarithromycin]]'''<br />cocaine<br />cyclosporine<br />'''[[daclatasvir]]'''<br />'''[[dapsone]]'''<br />'''[[darunavir]]'''<br />dexamethasone<br />dextromethorphan<br />diltiazem<br />docetaxel<br />domperidone<br />'''[[elbasvir]]'''<br />eplerenone
|'''[[erythromycin]]'''<br />[[estradiol]]<br />'''[[etravirine]]'''<br />[[felodipine]]<br />[[fentanyl]]<br />[[finasteride]]<br />'''[[fosamprenavir]]'''<br />'''[[grazoprevir]]'''<br />[[haloperidol]]<br />[[hydrocortisone]]<br />[[imitanib]]<br />'''[[indinavir]]'''<br />[[irinotecan]]<br />[[lidocaine]]<br />[[lovastatin]]<br />'''[[maraviroc]]'''<br />[[midazolam]]<br />[[nateglinide]]<br />'''[[nelfinavir]]'''<br />[[nifedipine]]<br />[[nisoldipine]]<br />[[nitrendipine]]<br />[[ondansetron]]<br />'''[[paritaprevir]]'''<br />[[pimozide]]<br />'''[[praziquantel]]'''
|'''[[erythromycin]]'''<br />estradiol<br />'''[[etravirine]]'''<br />felodipine<br />fentanyl<br />finasteride<br />'''[[fosamprenavir]]'''<br />'''[[grazoprevir]]'''<br />haloperidol<br />hydrocortisone<br />imitanib<br />'''[[indinavir]]'''<br />irinotecan<br />lidocaine<br />lovastatin<br />'''[[maraviroc]]'''<br />midazolam<br />nateglinide<br />'''[[nelfinavir]]'''
|[[progesterone]]<br />[[quetiapine]]<br />[[quinidine]]<br />'''[[quinine]]'''<br />[[risperidone]]<br />'''[[ritonavir]]'''<br />[[salmeterol]]<br />'''[[saquinavir]]'''<br />[[sildenafil]]<br />'''[[simeprevir]]'''<br />[[simvastatin]]<br />[[sirolimus]]<br />[[tacrolimus]]<br />[[tadalafil]]<br />[[taxol]]<br />[[terfenadine]]<br />[[testosterone]]<br />'''[[tipranavir]]'''<br />[[trazodone]]<br />[[triazolam]]<br />[[vardenafil]]<br />[[verapamil]]<br />[[vincristine]]<br />[[zaleplon]]<br />[[ziprasidone]]<br />[[zolpidem]]
nifedipine<br />nisoldipine<br />nitrendipine<br />ondansetron<br />'''[[paritaprevir]]'''<br />pimozide<br />'''[[praziquantel]]'''
|progesterone<br />quetiapine<br />quinidine<br />'''[[quinine]]'''<br />risperidone<br />'''[[ritonavir]]'''<br />salmeterol<br />'''[[saquinavir]]'''<br />sildenafil<br />'''[[simeprevir]]'''<br />simvastatin<br />sirolimus<br />tacrolimus<br />tadalafil<br />taxol<br />terfenadine<br />testosterone<br />'''[[tipranavir]]'''<br />trazodone<br />triazolam<br />vardenafil<br />verapamil<br />vincristine<br />zaleplon<br />ziprasidone<br />zolpidem
|-
|-
!CYP
!CYP
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|}
|}


[[Category:Antimicrobials]]
[[Category:Medications]]

Latest revision as of 17:29, 20 August 2020

CYP Inhibitors Inducers Substrates
CYP1A2 amiodarone
cimetidine
ciprofloxacin 		fluvoxamine
interferon
methoxsalen 		cigarette smoking
marijuana smoking
modafinil
nafcillin 		amitriptyline
caffeine
clomipramine
clozapine
cyclobenzaprine
estradiol
fluvoxamine
haloperidol 		mexiletine
naproxen
olanzapine
ondansetron
phenacetine
propranolol
riluzole
ropivacaine 		tacrine
theophylline
tizanidine
verapamil
R-warfarin
zileuton
zolmitriptan
CYP Inhibitors Inducers Substrates
CYP2B6 ticlopidine thiotepa phenobarbital
rifampin 		bupropion
cyclophosphamide 		efavirenz
ifosfamide 		methadone
CYP Inhibitors Inducers Substrates
CYP2C8 gemfibrozil
montelukast
pioglitazone 		quercetin
rosiglitazone
trimethoprim 		rifampin amodiaquine
dasabuvir 		cerivastatin
paclitaxel 		torsemide
repaglinide
CYP Inhibitors Inducers Substrates
CYP2C9 amiodarone
fenofibrate
fluconazole
fluvastatin
fluvoxamine
isoniazid 		probenecid
sertraline
sulfamethoxazole
teniposide
voriconazole
zafirlukast 		rifampin
secorbarbital 		amitriptyline
celecoxib
diclofenac
fluoxetine
fluvastatin
glipizide
glyburide
ibuprofen 		irbesartan
lornoxicam
losartan
meloxicam
nateglinide
omeprazole
phenytoin 		piroxicam
rosiglitazone
rosuvastatin
S-warfarin
tamoxifen
tolbutamide
torsemide
CYP Inhibitors Inducers Substrates
CYP2C19 cimetidine
esomeprazole
felbamate
fluoxetine
fluvoxamine
indomethacin
ketoconazole
lansoprazole 		modafinil
omeprazole
oxcarbazepine
pantoprazole
probenecid
rabeprazole
ticlopidine
topiramate 		carbamazepine
norethindrone
prednisone
rifampin 		carisoprodol
chloramphenicol
citalopram
clomipramine
cyclophosphamide
esomeprazole
hexobarbital
indomethacin 		lansoprazole
moclobemide
nelfinavir
nilutamide
omeprazole
pantoprazole
phenobarbital
phenytoin 		primidone
progesterone
proguanil
propranolol
rabeprazole
teniposide
voriconazole
CYP Inhibitors Inducers Substrates
CYP2D6 amiodarone
bupropion
celecoxib
chlorpheniramine
chlorpromazine
cimetidine
citalopram
clemastine
clomipramine
cocaine
diphenhydramine
doxepin
doxorubicin
duloxetine
escitalopram 		fluoxetine
hydroxyzine
metoclopramide
mibefradil
midodrine
moclobemide
paroxetine
perphenazine
quinidine
ranitidine
ritonavir
sertraline
terbinafine
ticlopidine 		dexamethasone
rifampin 		alprenolol
amitriptyline
amphetamine
aripiprazole
atomoxetine
carvedilol
chlorpheniramine
chlorpromazine
clomipramine
codeine 		debrisoquine
desipramine
dexfenfluramine
dextromethorphan
duloxetine
encainide
flecainide
fluoxetine
fluvoxamine
haloperidol 		imipramine
lidocaine
methoxyamphetamine
metoclopramide
paroxetine
perphenazine
propafenone
S-metoprolol
thioridazine
timolol
CYP Inhibitors Inducers Substrates
CYP2E1 disulfiram ethanol
isoniazid 		acetaminophen
chlorzoxazone
enflurane 		ethanol
halothane
isoflurane 		methoxyflurane
sevoflurane
CYP Inhibitors Inducers Substrates
CYP3A amiodarone
aprepitant
cimetidine
clarithromycin
cobicistat
delavirdine
diltiazem
elvitegravir
erythromycin
fluconazole
fluvoxamine
gestodene
imatinib
indinavir 		isavuconazonium
itraconazole
ketoconazole
mibefradil
mifepristone
nefazodone
nelfinavir
norfluoxetine
posaconazole
ritonavir
saquinavir
verapamil
voriconazole 		barbiturates
carbamazepine
efavirenz
glucocorticoids
modafinil
nevirapine
oxcarbazepine
phenobarbital
phenytoin
pioglitazone
rifabutin
rifampin
St. John's wort 		alfentanil
alprazolam
amlodipine
aprepitant
aripiprazole
artemisinin
astemizole
atazanavir
atorvastatin
bedaquiline
buspirone
cafergot
chlorpheniramine
cilostazol
clarithromycin
cocaine
cyclosporine
daclatasvir
dapsone
darunavir
dexamethasone
dextromethorphan
diltiazem
docetaxel
domperidone
elbasvir
eplerenone 		erythromycin
estradiol
etravirine
felodipine
fentanyl
finasteride
fosamprenavir
grazoprevir
haloperidol
hydrocortisone
imitanib
indinavir
irinotecan
lidocaine
lovastatin
maraviroc
midazolam
nateglinide
nelfinavir
nifedipine
nisoldipine
nitrendipine
ondansetron
paritaprevir
pimozide
praziquantel 		progesterone
quetiapine
quinidine
quinine
risperidone
ritonavir
salmeterol
saquinavir
sildenafil
simeprevir
simvastatin
sirolimus
tacrolimus
tadalafil
taxol
terfenadine
testosterone
tipranavir
trazodone
triazolam
vardenafil
verapamil
vincristine
zaleplon
ziprasidone
zolpidem
CYP Inhibitors Inducers Substrates
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