Bedaquiline

• Antituberculosis antibiotic used as second-line therapy
• Inhibits the ATP synthase proton pump in mycobacteria
• Member of the diarylquinoline class of antibiotics
• Adverse events include QTc prolongation, hepatitis, and possibly an increased risk of death
  • Others: arthralgias, dizziness, headache, hyperuremia, insomnia, myalgia, nausea, prolonged QTc, pruritus, and vomiting