Terbinafine
From IDWiki
Background
- Allylamine antifungal
- Inhibits ergosterol synthesis by inhibiting squalene epoxidase
Dosing
Topical
- Tinea pedis
- Terbinafine cream applied to affected areas twice daily for at least one week
- Terbinafine gel applied to affected area once daily at bedtime for at least 1 week
- Terbinafine spray applied to affected area once daily for at least one week
- Tinea corporis and tinea cruris: as above
Systemic
- Onychomycosis
- Continuous dosing: 250 mg PO once daily for 6 weeks (fingernails) or 12 weeks (toenails)
- Pulsed dosing: 250 mg PO once daily for 4 weeks, off for 4 weeks, then resume for 4 weeks
- Pulsed dosing: 250 mg PO once daily for 1 week repeated every 4 weeks for 3 months
- Sporotrichosis: 500 mg PO BID, continued for 2 to 4 weeks after resolution of all lesions (usual duration 3 to 6 months)
- Pulmonary aspergillosis: 5 to 15 mg/kg per day12
- Combination with other antifungals for resistant infections: anywhere from 250 mg daily to 500 mg every 12 hours
References
- ^ G.F. SCHIRALDI, S. LO CICERO, M.D. COLOMBO, D. ROSSATO, M. FERRARESE, E. SORESI. Refractory pulmonary aspergillosis: compassionate trial with terbinafine. British Journal of Dermatology. 1996;134:25-29. doi:10.1111/j.1365-2133.1996.tb15656.x.
- ^ G. F. Schiraldi, M. D. Colombo, S. Harari, S. Lo Cicero, G. Ziglio, M. Ferrarese, D. Rossato, E. Soresi. Terbinafine in the treatment of non‐immunocompromised compassionate cases of bronchopulmonary aspergillosis. Mycoses. 1996;39(1-2):5-12. doi:10.1111/j.1439-0507.1996.tb00077.x.
