Drug-drug interactions: Difference between revisions
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{| class="wikitable" |
{| class="wikitable" |
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! |
!CYP |
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! Inhibitors |
! colspan="2" |Inhibitors |
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! |
!Inducers |
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! Substrates |
! colspan="3" |Substrates |
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|- |
|- |
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|CYP1A2 |
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|[[amiodarone]]<br />[[cimetidine]]<br />'''[[ciprofloxacin]]''' |
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|[[fluvoxamine]]<br />'''[[interferon]]'''<br />[[methoxsalen]] |
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| cigarette smoking<br/>marijuana smoking<br/>modafinil<br/>'''[[nafcillin]]''' |
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|[[Nicotine use disorder|cigarette smoking]]<br />[[Cannabis use disorder|marijuana smoking]]<br />[[modafinil]]<br />'''[[nafcillin]]''' |
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| amitriptyline<br/>caffeine<br/>clomipramine<br/>clozapine<br/>cyclobenzaprine<br/>estradiol<br/>fluvoxamine<br/>haloperidol<br/>mexiletine<br/>naproxen<br/>olanzapine<br/>ondansetron<br/>phenacetine<br/>propranolol<br/>riluzole<br/>ropivacaine<br/>tacrine<br/>theophylline<br/>tizanidine<br/>verapamil<br/>R-warfarin<br/>zileuton<br/>zolmitriptan |
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|[[amitriptyline]]<br />[[caffeine]]<br />[[clomipramine]]<br />[[clozapine]]<br />[[cyclobenzaprine]]<br />[[estradiol]]<br />[[fluvoxamine]]<br />[[haloperidol]] |
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|[[mexiletine]]<br />[[naproxen]]<br />[[olanzapine]]<br />[[ondansetron]]<br />[[phenacetine]]<br />[[propranolol]]<br />[[riluzole]]<br />[[ropivacaine]] |
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|[[tacrine]]<br />[[theophylline]]<br />[[tizanidine]]<br />[[verapamil]]<br />[[Warfarin|R-warfarin]]<br />[[zileuton]]<br />[[zolmitriptan]] |
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|- |
|- |
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!CYP |
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| CYP2B6 |
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! colspan="2" |Inhibitors |
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| ticlopidine<br/>thiotepa |
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!Inducers |
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| phenobarbital<br/>'''[[rifampin]]''' |
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! colspan="3" |Substrates |
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| bupropion<br/>cyclophosphamide<br/>'''[[efavirenz]]'''<br/>ifosfamide<br/>methadone |
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|- |
|- |
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|CYP2B6 |
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| CYP2C8 |
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|[[ticlopidine]] |
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| gemfibrozil<br/>montelukast<br/>pioglitazone<br/>quercetin<br/>rosiglitazone<br/>'''[[trimethoprim]]''' |
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|[[thiotepa]] |
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|[[phenobarbital]]<br />'''[[rifampin]]''' |
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| amodiaquine<br/>'''[[dasabuvir]]'''<br/>cerivastatin<br/>paclitaxel<br/>torsemide<br/>repaglinide |
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|[[bupropion]]<br />[[cyclophosphamide]] |
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|'''[[efavirenz]]'''<br />[[ifosfamide]] |
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|[[methadone]] |
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|- |
|- |
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!CYP |
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| CYP2C9 |
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! colspan="2" |Inhibitors |
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| amiodarone<br/>fenofibrate<br/>'''[[fluconazole]]'''<br/>fluvastatin<br/>fluvoxamine<br/>'''[[isoniazid]]'''<br/>probenecid<br/>sertraline<br/>'''[[sulfamethoxazole]]'''<br/>teniposide<br/>'''[[voriconazole]]'''<br/>zafirlukast |
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!Inducers |
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| '''[[rifampin]]'''<br/>secorbarbital |
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! colspan="3" |Substrates |
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| amitriptyline<br/>celecoxib<br/>diclofenac<br/>fluoxetine<br/>fluvastatin<br/>glipizide<br/>glyburide<br/>ibuprofen<br/>irbesartan<br/>lornoxicam<br/>losartan<br/>meloxicam<br/>nateglinide<br/>omeprazole<br/>phenytoin<br/>piroxicam<br/>rosiglitazone<br/>rosuvastatin<br/>S-warfarin<br/>tamoxifen<br/>tolbutamide<br/>torsemide |
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|- |
|- |
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|CYP2C8 |
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| CYP2C19 |
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|[[gemfibrozil]]<br />[[montelukast]]<br />[[pioglitazone]] |
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| cimetidine<br/>esomeprazole<br/>felbamate<br/>fluoxetine<br/>fluvoxamine<br/>indomethacin<br/>'''[[ketoconazole]]'''<br/>lansoprazole<br/>modafinil<br/>omeprazole<br/>oxcarbazepine<br/>pantoprazole<br/>probenecid<br/>rabeprazole<br/>ticlopidine<br/>topiramate |
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|[[quercetin]]<br />[[rosiglitazone]]<br />'''[[trimethoprim]]''' |
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|'''[[rifampin]]''' |
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| carisoprodol<br/>'''[[chloramphenicol]]'''<br/>citalopram<br/>clomipramine<br/>cyclophosphamide<br/>esomeprazole<br/>hexobarbital<br/>indomethacin<br/>lansoprazole<br/>moclobemide<br/>'''[[nelfinavir]]'''<br/>nilutamide<br/>omeprazole<br/>pantoprazole<br/>phenobarbital<br/>phenytoin<br/>primidone<br/>progesterone<br/>'''[[proguanil]]'''<br/>propranolol<br/>rabeprazole<br/>teniposide<br/>'''[[voriconazole]]''' |
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|[[amodiaquine]]<br />'''[[dasabuvir]]''' |
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|[[cerivastatin]]<br />[[paclitaxel]] |
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|[[torsemide]]<br />[[repaglinide]] |
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|- |
|- |
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!CYP |
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| CYP2D6 |
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! colspan="2" |Inhibitors |
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| amiodarone<br/>bupropion<br/>celecoxib<br/>chlorpheniramine<br/>chlorpromazine<br/>cimetidine<br/>citalopram<br/>clemastine<br/>clomipramine<br/>cocaine<br/>diphenhydramine<br/>doxepin<br/>doxorubicin<br/>duloxetine<br/>escitalopram<br/>fluoxetine<br/>hydroxyzine<br/>metoclopramide<br/>mibefradil<br/>midodrine<br/>moclobemide<br/>paroxetine<br/>perphenazine<br/>quinidine<br/>ranitidine<br/>'''[[ritonavir]]'''<br/>sertraline<br/>terbinafine<br/>ticlopidine |
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!Inducers |
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| dexamethasone<br/>'''[[rifampin]]''' |
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! colspan="3" |Substrates |
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| alprenolol<br/>amitriptyline<br/>amphetamine<br/>aripiprazole<br/>atomoxetine<br/>carvedilol<br/>chlorpheniramine<br/>chlorpromazine<br/>clomipramine<br/>codeine<br/>debrisoquine<br/>desipramine<br/>dexfenfluramine<br/>dextromethorphan<br/>duloxetine<br/>encainide<br/>flecainide<br/>fluoxetine<br/>fluvoxamine<br/>haloperidol<br/>imipramine<br/>lidocaine<br/>methoxyamphetamine<br/>metoclopramide<br/>paroxetine<br/>perphenazine<br/>propafenone<br/>S-metoprolol<br/>thioridazine<br/>timolol |
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|- |
|- |
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|CYP2C9 |
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| CYP2E1 |
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|[[amiodarone]]<br />[[fenofibrate]]<br />'''[[fluconazole]]'''<br />[[fluvastatin]]<br />[[fluvoxamine]]<br />'''[[isoniazid]]''' |
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| disulfiram |
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|[[probenecid]]<br />[[sertraline]]<br />'''[[sulfamethoxazole]]'''<br />[[teniposide]]<br />'''[[voriconazole]]'''<br />[[zafirlukast]] |
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| ethanol<br/>'''[[isoniazid]]''' |
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|'''[[rifampin]]'''<br />[[secorbarbital]] |
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| acetaminophen<br/>chlorzoxazone<br/>enflurane<br/>ethanol<br/>halothane<br/>isoflurane<br/>methoxyflurane<br/>sevoflurane |
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|[[amitriptyline]]<br />[[celecoxib]]<br />[[diclofenac]]<br />[[fluoxetine]]<br />[[fluvastatin]]<br />[[glipizide]]<br />[[glyburide]]<br />[[ibuprofen]] |
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|[[irbesartan]]<br />[[lornoxicam]]<br />[[losartan]]<br />[[meloxicam]]<br />[[nateglinide]]<br />[[omeprazole]]<br />[[phenytoin]] |
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|[[piroxicam]]<br />[[rosiglitazone]]<br />[[rosuvastatin]]<br />[[Warfarin|S-warfarin]]<br />[[tamoxifen]]<br />[[tolbutamide]]<br />[[torsemide]] |
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|- |
|- |
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!CYP |
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| CYP3A |
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! colspan="2" |Inhibitors |
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| amiodarone<br/>aprepitant<br/>cimetidine<br/>'''[[clarithromycin]]'''<br/>'''[[cobicistat]]'''<br/>'''[[delavirdine]]'''<br/>diltiazem<br/>'''[[elvitegravir]]'''<br/>'''[[erythromycin]]'''<br/>'''[[fluconazole]]'''<br/>fluvoxamine<br/>gestodene<br/>imatinib<br/>'''[[indinavir]]'''<br/>'''[[isavuconazonium]]'''<br/>'''[[itraconazole]]'''<br/>'''[[ketoconazole]]'''<br/>mibefradil<br/>mifepristone<br/>nefazodone<br/>'''[[nelfinavir]]'''<br/>norfluoxetine<br/>'''[[posaconazole]]'''<br/>'''[[ritonavir]]'''<br/>'''[[saquinavir]]'''<br/>verapamil<br/>'''[[voriconazole]]''' |
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!Inducers |
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| barbiturates<br/>carbamazepine<br/>'''[[efavirenz]]'''<br/>glucocorticoids<br/>modafinil<br/>nevirapine<br/>oxcarbazepine<br/>phenobarbital<br/>phenytoin<br/>pioglitazone<br/>'''[[rifabutin]]'''<br/>'''[[rifampin]]'''<br/>St. John’s wort |
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! colspan="3" |Substrates |
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| alfentanil<br/>alprazolam<br/>amlodipine<br/>aprepitant<br/>aripiprazole<br/>'''[[artemisinin]]'''<br/>astemizole<br/>'''[[atazanavir]]'''<br/>atorvastatin<br/>'''[[bedaquiline]]'''<br/>buspirone<br/>cafergot<br/>chlorpheniramine<br/>cilostazol<br/>'''[[clarithromycin]]'''<br/>cocaine<br/>cyclosporine<br/>'''[[daclatasvir]]'''<br/>'''[[dapsone]]'''<br/>'''[[darunavir]]'''<br/>dexamethasone<br/>dextromethorphan<br/>diltiazem<br/>docetaxel<br/>domperidone<br/>'''[[elbasvir]]'''<br/>eplerenone<br/>'''[[erythromycin]]'''<br/>estradiol<br/>'''[[etravirine]]'''<br/>felodipine<br/>fentanyl<br/>finasteride<br/>'''[[fosamprenavir]]'''<br/>'''[[grazoprevir]]'''<br/>haloperidol<br/>hydrocortisone<br/>imitanib<br/>'''[[indinavir]]'''<br/>irinotecan<br/>lidocaine<br/>lovastatin<br/>'''[[maraviroc]]'''<br/>midazolam<br/>nateglinide<br/>'''[[nelfinavir]]'''<br/>nifedipine<br/>nisoldipine<br/>nitrendipine<br/>ondansetron<br/>'''[[paritaprevir]]'''<br/>pimozide<br/>'''[[praziquantel]]'''<br/>progesterone<br/>quetiapine<br/>quinidine<br/>'''[[quinine]]'''<br/>risperidone<br/>'''[[ritonavir]]'''<br/>salmeterol<br/>'''[[saquinavir]]'''<br/>sildenafil<br/>'''[[simeprevir]]'''<br/>simvastatin<br/>sirolimus<br/>tacrolimus<br/>tadalafil<br/>taxol<br/>terfenadine<br/>testosterone<br/>'''[[tipranavir]]'''<br/>trazodone<br/>triazolam<br/>vardenafil<br/>verapamil<br/>vincristine<br/>zaleplon<br/>ziprasidone<br/>zolpidem |
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|- |
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|CYP2C19 |
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|[[cimetidine]]<br />[[esomeprazole]]<br />[[felbamate]]<br />[[fluoxetine]]<br />[[fluvoxamine]]<br />[[indomethacin]]<br />'''[[ketoconazole]]'''<br />[[lansoprazole]] |
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|[[modafinil]]<br />[[omeprazole]]<br />[[oxcarbazepine]]<br />[[pantoprazole]]<br />[[probenecid]]<br />[[rabeprazole]]<br />[[ticlopidine]]<br />[[topiramate]] |
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|[[carbamazepine]]<br />[[norethindrone]]<br />[[prednisone]]<br />'''[[rifampin]]''' |
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|[[carisoprodol]]<br />'''[[chloramphenicol]]'''<br />[[citalopram]]<br />[[clomipramine]]<br />[[cyclophosphamide]]<br />[[esomeprazole]]<br />[[hexobarbital]]<br />[[indomethacin]] |
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|[[lansoprazole]]<br />[[moclobemide]]<br />'''[[nelfinavir]]'''<br />[[nilutamide]]<br />[[omeprazole]]<br />[[pantoprazole]]<br />[[phenobarbital]]<br />[[phenytoin]] |
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|[[primidone]]<br />[[progesterone]]<br />'''[[proguanil]]'''<br />[[propranolol]]<br />[[rabeprazole]]<br />[[teniposide]]<br />'''[[voriconazole]]''' |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|- |
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|CYP2D6 |
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|[[amiodarone]]<br />[[bupropion]]<br />[[celecoxib]]<br />[[chlorpheniramine]]<br />[[chlorpromazine]]<br />[[cimetidine]]<br />[[citalopram]]<br />[[clemastine]]<br />[[clomipramine]]<br />[[cocaine]]<br />[[diphenhydramine]]<br />[[doxepin]]<br />[[doxorubicin]]<br />[[duloxetine]]<br />[[escitalopram]] |
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|[[fluoxetine]]<br />[[hydroxyzine]]<br />[[metoclopramide]]<br />[[mibefradil]]<br />[[midodrine]]<br />[[moclobemide]]<br />[[paroxetine]]<br />[[perphenazine]]<br />[[quinidine]]<br />[[ranitidine]]<br />'''[[ritonavir]]'''<br />[[sertraline]]<br />[[terbinafine]]<br />[[ticlopidine]] |
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|[[dexamethasone]]<br />'''[[rifampin]]''' |
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|[[alprenolol]]<br />[[amitriptyline]]<br />[[amphetamine]]<br />[[aripiprazole]]<br />[[atomoxetine]]<br />[[carvedilol]]<br />[[chlorpheniramine]]<br />[[chlorpromazine]]<br />[[clomipramine]]<br />[[codeine]] |
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|[[debrisoquine]]<br />[[desipramine]]<br />[[dexfenfluramine]]<br />[[dextromethorphan]]<br />[[duloxetine]]<br />[[encainide]]<br />[[flecainide]]<br />[[fluoxetine]]<br />[[fluvoxamine]]<br />[[haloperidol]] |
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|[[imipramine]]<br />[[lidocaine]]<br />[[methoxyamphetamine]]<br />[[metoclopramide]]<br />[[paroxetine]]<br />[[perphenazine]]<br />[[propafenone]]<br />[[Metoprolol|S-metoprolol]]<br />[[thioridazine]]<br />[[timolol]] |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|- |
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|CYP2E1 |
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|[[disulfiram]] |
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| |
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|[[Alcohol use disorder|ethanol]]<br />'''[[isoniazid]]''' |
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|[[acetaminophen]]<br />[[chlorzoxazone]]<br />[[enflurane]] |
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|[[ethanol]]<br />[[halothane]]<br />[[isoflurane]] |
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|[[methoxyflurane]]<br />[[sevoflurane]] |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|- |
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|CYP3A |
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|[[amiodarone]]<br />[[aprepitant]]<br />[[cimetidine]]<br />'''[[clarithromycin]]'''<br />'''[[cobicistat]]'''<br />'''[[delavirdine]]'''<br />[[diltiazem]]<br />'''[[elvitegravir]]'''<br />'''[[erythromycin]]'''<br />'''[[fluconazole]]'''<br />[[fluvoxamine]]<br />[[gestodene]]<br />[[imatinib]]<br />'''[[indinavir]]''' |
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|'''[[isavuconazonium]]'''<br />'''[[itraconazole]]'''<br />'''[[ketoconazole]]'''<br />[[mibefradil]]<br />[[mifepristone]]<br />[[nefazodone]]<br />'''[[nelfinavir]]'''<br />[[norfluoxetine]]<br />'''[[posaconazole]]'''<br />'''[[ritonavir]]'''<br />'''[[saquinavir]]'''<br />[[verapamil]]<br />'''[[voriconazole]]''' |
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|[[barbiturates]]<br />[[carbamazepine]]<br />'''[[efavirenz]]'''<br />[[glucocorticoids]]<br />[[modafinil]]<br />[[nevirapine]]<br />[[oxcarbazepine]]<br />[[phenobarbital]]<br />[[phenytoin]]<br />[[pioglitazone]]<br />'''[[rifabutin]]'''<br />'''[[rifampin]]'''<br />[[St. John's wort]] |
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|[[alfentanil]]<br />[[alprazolam]]<br />[[amlodipine]]<br />[[aprepitant]]<br />[[aripiprazole]]<br />'''[[artemisinin]]'''<br />[[astemizole]]<br />'''[[atazanavir]]'''<br />[[atorvastatin]]<br />'''[[bedaquiline]]'''<br />[[buspirone]]<br />[[cafergot]]<br />[[chlorpheniramine]]<br />[[cilostazol]]<br />'''[[clarithromycin]]'''<br />[[cocaine]]<br />[[cyclosporine]]<br />'''[[daclatasvir]]'''<br />'''[[dapsone]]'''<br />'''[[darunavir]]'''<br />[[dexamethasone]]<br />[[dextromethorphan]]<br />[[diltiazem]]<br />[[docetaxel]]<br />[[domperidone]]<br />'''[[elbasvir]]'''<br />[[eplerenone]] |
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|'''[[erythromycin]]'''<br />[[estradiol]]<br />'''[[etravirine]]'''<br />[[felodipine]]<br />[[fentanyl]]<br />[[finasteride]]<br />'''[[fosamprenavir]]'''<br />'''[[grazoprevir]]'''<br />[[haloperidol]]<br />[[hydrocortisone]]<br />[[imitanib]]<br />'''[[indinavir]]'''<br />[[irinotecan]]<br />[[lidocaine]]<br />[[lovastatin]]<br />'''[[maraviroc]]'''<br />[[midazolam]]<br />[[nateglinide]]<br />'''[[nelfinavir]]'''<br />[[nifedipine]]<br />[[nisoldipine]]<br />[[nitrendipine]]<br />[[ondansetron]]<br />'''[[paritaprevir]]'''<br />[[pimozide]]<br />'''[[praziquantel]]''' |
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|[[progesterone]]<br />[[quetiapine]]<br />[[quinidine]]<br />'''[[quinine]]'''<br />[[risperidone]]<br />'''[[ritonavir]]'''<br />[[salmeterol]]<br />'''[[saquinavir]]'''<br />[[sildenafil]]<br />'''[[simeprevir]]'''<br />[[simvastatin]]<br />[[sirolimus]]<br />[[tacrolimus]]<br />[[tadalafil]]<br />[[taxol]]<br />[[terfenadine]]<br />[[testosterone]]<br />'''[[tipranavir]]'''<br />[[trazodone]]<br />[[triazolam]]<br />[[vardenafil]]<br />[[verapamil]]<br />[[vincristine]]<br />[[zaleplon]]<br />[[ziprasidone]]<br />[[zolpidem]] |
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|- |
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!CYP |
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! colspan="2" |Inhibitors |
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!Inducers |
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! colspan="3" |Substrates |
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|} |
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[[Category:Medications]] |
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[[Category:Antimicrobials]] |