Thrombocytopenia: Difference between revisions
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==Differential Diagnosis== |
==Differential Diagnosis== |
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*Pseudothrombocytopenia |
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*Decreased production |
*Decreased production |
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**Viral infection |
**Viral infection |
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*Destruction/Consumption |
*Destruction/Consumption |
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**[[Immune-mediated thrombocytopenic purpura]] (ITP) |
**[[Immune-mediated thrombocytopenic purpura]] (ITP) |
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***Primary ITP |
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***[[Hepatitis C]], [[HIV]], and [[Helicobacter pylori]] |
***[[Hepatitis C]], [[HIV]], and [[Helicobacter pylori]]; also [[CMV]], [[EBV]], [[VZV]], [[Zika virus]] |
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***Medications: [[abciximab]], beta-lactams (including [[penicillins]] and [[cephalosporins]]), [[carbamazepine]], [[epifitabide]], gold compounds, [[Heparin-inducted thrombocytopenia|heparin]], [[linezolid]], [[MMR vaccine]], [[phenytoin]], [[piperacillin]], [[quinidine]], [[quinine]], [[rifampin]], sulfonamides (including [[TMP-SMX]]), [[valproic acid]], and [[vancomycin]] |
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***Autoimmune: [[antiphospholipid syndrome]], [[Evans syndrome]], [[IBD]], [[RA]], [[SLE]] |
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***[[CVID]] |
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***[[CLL]] |
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***[[Lymphoma]] |
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**[[Thrombotic microangiopathy]] |
**[[Thrombotic microangiopathy]] |
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***[[TTP]]/[[HUS]], other TMAs |
***[[TTP]]/[[HUS]], other TMAs |
Latest revision as of 17:01, 25 March 2024
Differential Diagnosis
- Pseudothrombocytopenia
- Decreased production
- Viral infection
- Malignancy
- Destruction/Consumption
- Immune-mediated thrombocytopenic purpura (ITP)
- Primary ITP
- Hepatitis C, HIV, and Helicobacter pylori; also CMV, EBV, VZV, Zika virus
- Medications: abciximab, beta-lactams (including penicillins and cephalosporins), carbamazepine, epifitabide, gold compounds, heparin, linezolid, MMR vaccine, phenytoin, piperacillin, quinidine, quinine, rifampin, sulfonamides (including TMP-SMX), valproic acid, and vancomycin
- Autoimmune: antiphospholipid syndrome, Evans syndrome, IBD, RA, SLE
- CVID
- CLL
- Lymphoma
- Thrombotic microangiopathy
- Immune-mediated thrombocytopenic purpura (ITP)
- Sequestration
Investigations
- Rule out secondary causes with hepatitis C virus, HIV, and Helicobacter pylori serology