Thrombocytopenia: Difference between revisions

Latest revision as of 17:01, 25 March 2024

Rule out secondary causes with hepatitis C virus, HIV, and Helicobacter pylori serology

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-== Differential Diagnosis ==
+==Differential Diagnosis==
+*Pseudothrombocytopenia
-* Decreased production
+*Decreased production
-** Viral infections
+**Viral infection
-** Malignancies
+**[[Malignancy]]
-* Destruction/Consumptiom
+*Destruction/Consumption
-** Immune-mediated thrombocytopenic purpura (ITP)
+**[[Immune-mediated thrombocytopenic purpura]] (ITP)
-*** Hepatitis C, HIV, and ''H. pylori''
+***Primary ITP
-** Thrombotic microangiopathy
+***[[Hepatitis C]], [[HIV]], and [[Helicobacter pylori]]; also [[CMV]], [[EBV]], [[VZV]], [[Zika virus]]
-*** TTP/HUS, other TMAs
+***Medications: [[abciximab]], beta-lactams (including [[penicillins]] and [[cephalosporins]]), [[carbamazepine]], [[epifitabide]], gold compounds, [[Heparin-inducted thrombocytopenia|heparin]], [[linezolid]], [[MMR vaccine]], [[phenytoin]], [[piperacillin]], [[quinidine]], [[quinine]], [[rifampin]], sulfonamides (including [[TMP-SMX]]), [[valproic acid]], and [[vancomycin]]
-* Sequestration
+***Autoimmune: [[antiphospholipid syndrome]], [[Evans syndrome]], [[IBD]], [[RA]], [[SLE]]
-** Splenomegaly
+***[[CVID]]
+***[[CLL]]
+***[[Lymphoma]]
+**[[Thrombotic microangiopathy]]
+***[[TTP]]/[[HUS]], other TMAs
+*Sequestration
+**[[Splenomegaly]]
-== Investigations ==
+==Investigations==
-* Rule out secondary causes with HCV, HIV, and H. pylori serology
+*Rule out secondary causes with [[hepatitis C virus]], [[HIV]], and [[Helicobacter pylori]] serology
 [[Category:Hematology]]