Thrombotic microangiopathy: Difference between revisions

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*Syndrome of [[microangiopathic hemolytic anemia]], [[thrombocytopenia]], and microvascular thrombosis leading to organ dysfunction
 
*Syndrome of [[microangiopathic hemolytic anemia]], [[thrombocytopenia]], and microvascular thrombosis leading to organ dysfunction
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{| class="wikitable"
*Primary
 
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!Disease
**[[Thrombotic thrombocytopenia purpura]]
 
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!Clinical Clues
**[[Hemolytic-uremic syndrome]]
 
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|-
**[[Atypical hemolytic-uremic syndrome]]
 
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! colspan="2" |Primary
**[[HELLP syndrome]]
 
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|-
*Associated with coexisting condition
 
 
|[[Thrombotic thrombocytopenia purpura]]
**Autoimmune disease, including [[systemic lupus erythematosus]] or [[antiphospholid antibody syndrome]]
 
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|PT/INR and PTT are normal
**Drugs, including [[quinine]], [[ticlopidine]], and [[chemotherapy]] ([[mitomycin]], [[gemcitabine]], [[cyclosporine]], and [[tacrolimus]], though it may also be caused by the underlying condition)
 
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|-
**[[Sepsis]]
 
 
|[[Hemolytic-uremic syndrome]]
**[[DIC]]
 
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|PT/INR and PTT are normal, severe AKI
**[[Malignancy]]
 
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|-
**[[HIV]]
 
 
|[[Atypical hemolytic-uremic syndrome]]
 
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|PT/INR and PTT are normal, severe AKI
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|-
 
|[[HELLP syndrome]]
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|pregnancy
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|-
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! colspan="2" |Secondary
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|-
 
|Autoimmune disease, including [[systemic lupus erythematosus]] or [[antiphospholid antibody syndrome]]
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|
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|-
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|[[Drug-induced thrombotic microangiopathy]]
 
|including [[quinine]], [[ticlopidine]], and [[chemotherapy]] ([[mitomycin]], [[gemcitabine]], [[cyclosporine]], and [[tacrolimus]], though it may also be caused by the underlying condition
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|-
 
|[[Sepsis]]
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|
  +
|-
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|[[Secondary hemolytic-uremic syndrome]]
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|most commonly from [[Streptococcus pneumoniae]] or [[influenza]]
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|-
 
|[[DIC]]
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|PT/INR and PTT are prolonged
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|-
 
|[[Malignancy]]
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|
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|-
 
|[[HIV]]
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|
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|}
 
[[Category:Hematology]]
 
[[Category:Hematology]]
 
[[Category:Thrombosis]]
 
[[Category:Thrombosis]]

Latest revision as of 07:26, 19 March 2024

Disease Clinical Clues
Primary
Thrombotic thrombocytopenia purpura PT/INR and PTT are normal
Hemolytic-uremic syndrome PT/INR and PTT are normal, severe AKI
Atypical hemolytic-uremic syndrome PT/INR and PTT are normal, severe AKI
HELLP syndrome pregnancy
Secondary
Autoimmune disease, including systemic lupus erythematosus or antiphospholid antibody syndrome
Drug-induced thrombotic microangiopathy including quinine, ticlopidine, and chemotherapy (mitomycin, gemcitabine, cyclosporine, and tacrolimus, though it may also be caused by the underlying condition
Sepsis
Secondary hemolytic-uremic syndrome most commonly from Streptococcus pneumoniae or influenza
DIC PT/INR and PTT are prolonged
Malignancy
HIV