Intrinsic antibiotic resistance: Difference between revisions

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== Background ==
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* Inherent or innate antimicrobial resistance that is present in all or almost all wild-type isolates of a given species
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==Enterobacterales==
  
==Enterobacterales==
 
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![[Colistin|CST]]
  
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|[[Citrobacter freundii]]
  
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|[[Enterobacter cloacae]]
  
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|[[Escherichia coli]]
  
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|[[Morganella morganii]]
  
|[[Morganella morganii]]
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|[[Proteus vulgaris]]
  
|[[Proteus vulgaris]]
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|[[Providencia rettgeri]]
  
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|[[Providencia stuartii]]
  
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|[[Raoultella species]]
  
|[[Raoultella species]]
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|[[Salmonella species]]
  
|[[Salmonella species]]
 
[[Shigella species]]
  
[[Shigella species]]
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|[[Yersinia enterocolitica]]
  
|[[Yersinia enterocolitica]]
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* The [[Morganellaceae]] may have elevated MICs to [[imipenem]], but should be reported as susceptible if susceptible in vitro
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* [[Providencia stuartii]] is intrinsically resistant to [[gentamicin]] and [[tobramycin]] but not to [[amikacin]]
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* No intrinsic resistance to third-generation cephalosporins, [[cefepime]], [[aztreonam]], [[ticarcillin-clavulanic acid]], [[piperacillin-tazobactam]], and [[carbapenems]]
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* All are intrinsically resistance to [[clindamycin]], [[daptomycin]], [[fusidic acid]], [[vancomycin]], [[lipoglycopeptides]] (vancins and planins), [[linezolid]], [[tedizolid]], [[quinupristin-dalfopristin]], [[rifampin]], [[macrolides]] (with the exception of [[Salmonella]] and [[Shigella]] with [[azithromycin]])
   
 
==Non-Enterobacterales==
  
==Non-Enterobacterales==
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* [[Stenotrophomonas maltophilia]] is intrinsically resistant to [[tetracycline]] but not to [[doxycycline]], [[minocycline]], or [[tigecycline]]
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== Staphylococci ==
  
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* Non-fermentative Gram-negative bacteria are also intrinsically resistant to [[penicillin]], first- and second-generation cephalosporins, [[cephamycins]], [[clindamycin]], [[daptomycin]], [[daptomycin]], [[fusidic acid]], [[vancomycin]], [[linezolid]], [[macrolides]], [[quinupristin-dalfopristin]], and [[rifampin]]
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==Staphylococci==
 
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== Enterococcus ==
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==Enterococcus==
 
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* In vitro susceptibility but clinically ineffective: cephalosporins, aminoglycosides, clindamycin, and cotrimoxazole
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*In vitro susceptibility but clinically ineffective: cephalosporins, [[aminoglycosides]], [[clindamycin]], and [[cotrimoxazole]]
   
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== Anaerobic Gram-Positive Bacilli ==
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==Anaerobic Gram-Positive Bacilli==
 
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== Anaerobic Gram-Negative Bacilli ==
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==Anaerobic Gram-Negative Bacilli==
 
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== Further Reading ==
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* CLSI M100-ED30:2020 Performance Standards for Antimicrobial Susceptibility Testing, 30th Edition
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[[Category:Antibiotics]]
  
[[Category:Antibiotics]]

Revision as of 11:36, 10 September 2020

Background

  • Inherent or innate antimicrobial resistance that is present in all or almost all wild-type isolates of a given species

Enterobacterales

Organism AMP AMC SAM TIC CFZ FOX CXM IMI TET TGC NIT CST AGs AZM
Citrobacter freundii R R R R R R R
Citrobacter koseri R R R
Enterobacter cloacae R R R R R R
Escherichia coli R
Hadnia alvei R R R R R R
Klebsiella aerogenes R R R R R R
Klebsiella pneumoniae

Klebsiella oxytoca

R R R
Morganella morganii R R R R ± R R R R
Proteus mirabilis ± R R R R R
Proteus vulgaris R R R ± R R R R R
Providencia rettgeri R R R ± R R R R R
Providencia stuartii R R R ± R R R R ± R
Raoultella species R R R
Salmonella species

Shigella species

Serratia marcescens R R R R R R R R R
Yersinia enterocolitica R R R R R

Non-Enterobacterales

Organism AMP PIP TIC SAM AMC TZP CTX CRO CAZ FEP ATM IMI MEM ETP CST AGs TET/TGC TMP SXT CHL FOF
Acinetobacter baumannii R R R R R R R
Burkholderia cepacia R R R R R ± ± ± ± ± ± R R ± ± R
Pseudomonas aeruginosa R R R R R R R R R R
Stenotrophomonas maltophilia R R R R R R R R R R R R R ± R R

Staphylococci

NOVO FOF FA AZT CST NAL
Staphylococcus aureus R R R
Staphylococcus lugdenensis R R R
Staphylococcus epidermidis R R R
Staphylococcus haemolyticus R R R
Staphylococcus saprophyticus R R R R R R
Staphylococcus capitis R R R R
Staphylococcus cohnii R R R R
Staphylococcus xylosus R R R R

Enterococcus

Cephalosporins VAN TEC AGs CLI Q-D TMP SXT FA
Enterococcus faecalis R R R R R R R
Enterococcus faecium R R R R R R
Enterococcus gallinarum R R R R R R R R
Enterococcus casseliflavus R R R R R R R R

Anaerobic Gram-Positive Bacilli

VAN AGs
Clostridium species R
Clostridioides difficile R
Clostridium innocuum R R

Anaerobic Gram-Negative Bacilli

AGs PEN AMP FQs
Bacteroides species R R R
Fusobacterium canifelinum R R

Further Reading

  • CLSI M100-ED30:2020 Performance Standards for Antimicrobial Susceptibility Testing, 30th Edition
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