Antifungal spectrum of activity: Difference between revisions

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{| class="wikitable"
  
{| class="wikitable"
−
! Organism
 +
! rowspan="2" |Organism
−
!align="center"| [[Amphotericin B|AmB]]
 +
! rowspan="2" |[[Amphotericin B|AmB]]
  +
! colspan="4" |Triazoles
⚫
!align="center"| [[Fluconazole|Fluc]]
  
  +
! colspan="3" |Echinocandins
⚫
!align="center"| [[Itraconazole|Itra]]
  
−
!align="center"| [[Voriconazole|Vori]]
 +
! rowspan="2" |[[Flucytasine|Flucyt]]
⚫
!align="center"| [[Posaconazole|Posa]]
  
⚫
!align="center"| [[Anidulafungin|Anidula]]
  
⚫
!align="center"| [[Caspofungin|Caspo]]
  
⚫
!align="center"| [[Micafungin|Mica]]
  
⚫
!align="center"| [[Flucytasine|Flucyt]]
  
 
|-
  
|-
  ⚫
! align="center" |[[Fluconazole|Fluc]]
⚫
| [[Aspergillus species]]
  
  ⚫
! align="center" |[[Itraconazole|Itra]]
  ⚫
! align="center" |[[Voriconazole|Vori]]
  ⚫
! align="center" |[[Posaconazole|Posa]]
  ⚫
! align="center" |[[Anidulafungin|Anidula]]
  ⚫
! align="center" |[[Caspofungin|Caspo]]
  ⚫
! align="center" |[[Micafungin|Mica]]
  +
|-
  ⚫
|[[Aspergillus]]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
|  [[Aspergillus flavus|''A. flavus'']]
 +
| [[Aspergillus flavus|''A. flavus'']]
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
|  [[Aspergillus fumigatus|''A. fumigatus'']]
 +
| [[Aspergillus fumigatus|''A. fumigatus'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
|  [[Aspergillus terreus|''A. terreus'']]
 +
| [[Aspergillus terreus|''A. terreus'']]
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
|  [[Aspergillus niger|''A. niger'']]
 +
| [[Aspergillus niger|''A. niger'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| [[Candida species]]
 +
|[[Candida]]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  [[Candida albicans|''C. albicans'']]
 +
| [[Candida albicans|''C. albicans'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  [[Candida glabrata|''C. glabrata'']]
 +
| [[Candida glabrata|''C. glabrata'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  [[Candida krusei|''C. krusei'']]
 +
| [[Candida krusei|''C. krusei'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
 
|-
  
|-
−
|  [[Candida lusitaniae|''C. lusitaniae'']]
 +
| [[Candida lusitaniae|''C. lusitaniae'']]
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  [[Candida parapsilosis|''C. parapsilosis'']]
 +
| [[Candida parapsilosis|''C. parapsilosis'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  [[Candida tropicalis|''C. tropicalis'']]
 +
| [[Candida tropicalis|''C. tropicalis'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
| [[Cryptococcus neoformans]]
 +
|[[Cryptococcus neoformans]]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
| [[Coccidioides imitis|''Coccidioides'']]
 +
|[[Coccidioides imitis|''Coccidioides'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| [[Blastomyces dermatitidis|''Blastomyces'']]
 +
|[[Blastomyces dermatitidis|''Blastomyces'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| [[Histoplasma capsulatum|''Histoplasma'']]
 +
|[[Histoplasma capsulatum|''Histoplasma'']]
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| [[Fusarium species]]
 +
|[[Fusarium]]
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| ''[[Scedosporium apiospermum]]''
 +
|''[[Scedosporium apiospermum]]''
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| ''[[Scedosporium prolificans]]''
 +
|''[[Scedosporium prolificans]]''
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| [[Zygomycetes]]
 +
|[[Zygomycetes]]
−
| style="text-align:center;background-color:lemonchiffon" | ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
| style="text-align:center;background-color:lightgreen" | +
  
| style="text-align:center;background-color:lightgreen" | +
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
−
| style="text-align:center;background-color:indianred" | –
 +
| style="text-align:center;background-color:indianred" |–
 
|}
  
|}
   
−
''Aspergillus ustus'' is resistant to azoles and echinocandins, and variable resistance to amphotericin (though still susceptible to terbinafine)
 +
* [[Aspergillus ustus]] is resistant to azoles and echinocandins, and variable resistance to [[amphotericin]] (though still susceptible to [[terbinafine]])
   
−
'''Source:''' Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, [https://doi.org/10.1086/504492 https://doi.org/10.1086/504492]
 +
'''Source:''' Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492
   
 
[[Category:Antifungals]]
  
[[Category:Antifungals]]

Latest revision as of 06:50, 1 February 2022

Organism AmB Triazoles Echinocandins Flucyt
Fluc Itra Vori Posa Anidula Caspo Mica
Aspergillus + – + + + + + + –
 A. flavus ± – + + + + + + –
 A. fumigatus + – + + + + + + –
 A. terreus – – + + + + + + –
 A. niger + – ± + + + + + –
Candida + + + + + + + + +
 C. albicans + + + + + + + + +
 C. glabrata + ± ± + + + + + +
 C. krusei + – ± + + + + + ±
 C. lusitaniae – + + + + + + + +
 C. parapsilosis + + + + + ± ± ± +
 C. tropicalis + + + + + + + + +
Cryptococcus neoformans + + + + + – – – +
Coccidioides + + + + + ± ± ± –
Blastomyces + + + + + ± ± ± –
Histoplasma + + + + + ± ± ± –
Fusarium ± – – + + – – – –
Scedosporium apiospermum ± – ± + + – – – –
Scedosporium prolificans – – – ± ± – – – –
Zygomycetes ± – – – + – – – –

Source: Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492

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