Caspofungin

From IDWiki

Background

  • Echinocandin antifungal

Mechanism of Action

  • Like all echinocandins, inhibits β-D-glucan synthase

Spectrum of Activity

Pharmacokinetics and Pharmacodynamics

  • Only 2% excreted unchanged in the kidney

Dosing

Pediatric Dosing

  • Casponfungin 70 mg/m2 IV followed by 50 mg/m2 IV daily

Hepatic Dosing

  • Reduce to 35 mg IV daily in cases of moderate hepatic impairment

Renal Dosing

  • No specific recommendations

Safety

Adverse Drug Events

  • Fevers, chills, phlebitis/thrombophlebitis, tachycardia, nausea, vomiting, rash, abdominal pain, headache, and diarrhea
  • Modest liver enzyme elevations

Monitoring

  • Liver enzymes
  • No specific recommendations