Antifungal spectrum of activity: Difference between revisions

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{| class="wikitable"
  
{| class="wikitable"
−
! Organism
 +
! rowspan="2" |Organism
−
!align="center"| AmB
 +
! rowspan="2" |[[Amphotericin B|AmB]]
  +
! colspan="4" |Triazoles
−
!align="center"| Fluc
  
  +
! colspan="3" |Echinocandins
−
!align="center"| Itra
  
  +
! rowspan="2" |[[Flucytasine|Flucyt]]
−
!align="center"| Vori
  
−
!align="center"| Posa
  
−
!align="center"| Anidula
  
−
!align="center"| Caspo
  
−
!align="center"| Mica
  
−
!align="center"| Flucyt
  
 
|-
  
|-
  +
! align="center" |[[Fluconazole|Fluc]]
−
| ''Aspergillus'' spp.
  
−
|align="center"| +
 +
! align="center" |[[Itraconazole|Itra]]
−
|align="center"| –
 +
! align="center" |[[Voriconazole|Vori]]
−
|align="center"| +
 +
! align="center" |[[Posaconazole|Posa]]
−
|align="center"| +
 +
! align="center" |[[Anidulafungin|Anidula]]
−
|align="center"| +
 +
! align="center" |[[Caspofungin|Caspo]]
−
|align="center"| +
 +
! align="center" |[[Micafungin|Mica]]
−
|align="center"| +
  
−
|align="center"| +
  
−
|align="center"| –
  
 
|-
  
|-
  +
|[[Aspergillus]]
−
|  ''A. flavus''
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
|  ''A. fumigatus''
 +
| [[Aspergillus flavus|''A. flavus'']]
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
|  ''A. terreus''
 +
| [[Aspergillus fumigatus|''A. fumigatus'']]
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
|  ''A. niger''
 +
| [[Aspergillus terreus|''A. terreus'']]
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
  +
| [[Aspergillus niger|''A. niger'']]
−
| ''Candida'' spp.
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
  
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
  
 
|-
  
|-
  +
|[[Candida]]
−
|  ''C. albicans''
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  ''C. glabrata''
 +
| [[Candida albicans|''C. albicans'']]
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  ''C. krusei''
 +
| [[Candida glabrata|''C. glabrata'']]
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
  
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
 
|-
  
|-
−
|  ''C. lusitaniae''
 +
| [[Candida krusei|''C. krusei'']]
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
  
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
 
|-
  
|-
−
|  ''C. parapsilosis''
 +
| [[Candida lusitaniae|''C. lusitaniae'']]
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| +
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
−
|  ''C. tropicalis''
 +
| [[Candida parapsilosis|''C. parapsilosis'']]
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
  +
| [[Candida tropicalis|''C. tropicalis'']]
−
| ''Cryptococcus neoformans''
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
 
|-
  
|-
  +
|[[Cryptococcus neoformans]]
−
| ''Coccidioides'' spp.
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
 
|-
  
|-
  +
|[[Coccidioides imitis|''Coccidioides'']]
−
| ''Blastomyces''
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
  +
|[[Blastomyces dermatitidis|''Blastomyces'']]
−
| ''Histoplasma'' spp.
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
  +
|[[Histoplasma capsulatum|''Histoplasma'']]
−
| ''Fusarium'' spp.
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
  
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
  
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
  +
|[[Fusarium]]
−
| ''Scedosporium apiospermum''
  
−
|align="center"| ±
 +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| ±
  
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| +
 +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
−
| ''Scedosporium prolificans''
 +
|''[[Scedosporium apiospermum]]''
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
  +
| style="text-align:center;background-color:lightgreen" | +
−
|align="center"| ±
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
 
|-
  
|-
  +
|''[[Scedosporium prolificans]]''
−
| Zygomycetes
  
  +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| ±
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| –
  
  +
| style="text-align:center;background-color:lemonchiffon" |±
−
|align="center"| +
  
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
−
|align="center"| –
 +
| style="text-align:center;background-color:indianred" |–
  +
|-
  +
|[[Zygomycetes]]
  +
| style="text-align:center;background-color:lemonchiffon" |±
  +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:lightgreen" | +
  +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:indianred" |–
  +
| style="text-align:center;background-color:indianred" |–
 
|}
  
|}
   
−
''Aspergillus ustus'' is resistant to azoles and echinocandins, and variable resistance to amphotericin (though still susceptible to terbinafine)
 +
* [[Aspergillus ustus]] is resistant to azoles and echinocandins, and variable resistance to [[amphotericin]] (though still susceptible to [[terbinafine]])
   
−
'''Source:''' Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, [https://doi.org/10.1086/504492 https://doi.org/10.1086/504492]
 +
'''Source:''' Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492
   
 
[[Category:Antifungals]]
  
[[Category:Antifungals]]

Latest revision as of 06:50, 1 February 2022

Organism AmB Triazoles Echinocandins Flucyt
Fluc Itra Vori Posa Anidula Caspo Mica
Aspergillus + – + + + + + + –
 A. flavus ± – + + + + + + –
 A. fumigatus + – + + + + + + –
 A. terreus – – + + + + + + –
 A. niger + – ± + + + + + –
Candida + + + + + + + + +
 C. albicans + + + + + + + + +
 C. glabrata + ± ± + + + + + +
 C. krusei + – ± + + + + + ±
 C. lusitaniae – + + + + + + + +
 C. parapsilosis + + + + + ± ± ± +
 C. tropicalis + + + + + + + + +
Cryptococcus neoformans + + + + + – – – +
Coccidioides + + + + + ± ± ± –
Blastomyces + + + + + ± ± ± –
Histoplasma + + + + + ± ± ± –
Fusarium ± – – + + – – – –
Scedosporium apiospermum ± – ± + + – – – –
Scedosporium prolificans – – – ± ± – – – –
Zygomycetes ± – – – + – – – –

Source: Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492

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