Antibiotic spectrum index: Difference between revisions

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** Penicillin-resistant [[pneumococcus]] (PRP)
 
** Penicillin-resistant [[pneumococcus]] (PRP)
 
** [[Moraxella]] and [[Haemophilus influenzae]]
 
** [[Moraxella]] and [[Haemophilus influenzae]]
** [[Mycoplasma]] and [[Chlamydophila]]
+
** [[Mycoplasma]] and [[Chlamydophila]] (atypicals)
 
** [[Anaerobes]] (in general)
 
** [[Anaerobes]] (in general)
 
** [[Bacteriodes fragilis]] (specifically)
 
** [[Bacteriodes fragilis]] (specifically)
Line 17: Line 17:
 
* For each patient, the number of points for every antibiotic is added to give a total daily ASI
 
* For each patient, the number of points for every antibiotic is added to give a total daily ASI
   
== Spectrum Indices ==
+
== Working Ranking ==
  +
{| class="wikitable"
 
  +
* The following is a reasonable list of commonly-used antibiotics, order from broadest to narrowest, not based on the ASI
  +
* [[Cefiderocol]], [[Colistin]], [[Polymyxin B]], [[Meropenem-vaborbactam]], [[Imipenem-relebactam]], [[Ceftazidime-avibactam]], [[Ceftolozane-tazobactam]], [[Tigecycline]], [[Meropenem]], [[Doripenem]], [[Ertapenem]], [[Piperacillin-tazobactam]], [[Ticarcillin-clavulanate]], [[Fosfomycin]], [[Moxifloxacin]], [[Levofloxacin]], [[Ciprofloxacin]], [[Doxycycline]], [[Amikacin]], [[Tobramycin]], [[Gentamicin]], [[Cefipime]], [[Ceftazidime]], [[Trimethoprim-sulfamethoxazole]], [[Ampicillin-sulbactam]], [[Amoxicillin-clavulanate]], [[Ceftaroline]], [[Ceftriaxone]], [[Cefuroxime]], [[Cefazolin]], [[Ampicillin]], [[Amoxicillin]]
  +
  +
== Sample Spectrum Index ==
 
{| class="wikitable sortable"
 
!Antibiotic
 
!Antibiotic
 
!MSSA
 
!MSSA
  +
!E.faeca
!Enterococcus
 
 
!Anaerobes
 
!Anaerobes
 
!Bacteroides
 
!Bacteroides
  +
!M/H.flu
!Moraxella/Haemophilus
 
  +
!E/K
!Escherichia/Klebsiella
 
 
!AmpC
 
!AmpC
 
!ESBL
 
!ESBL
  +
!Pseudo
!Pseudomonas
 
 
!MRSA
 
!MRSA
  +
!PRP
!Pen-R pneumococcus
 
 
!VRE
 
!VRE
  +
!Atypicals
!Atypical
 
 
!MDRO
 
!MDRO
 
!ASI
 
!ASI
 
|-
 
|-
|Dicloxacillin
+
|[[Dicloxacillin]]
 
|1
 
|1
 
|0
 
|0
Line 53: Line 58:
 
|1
 
|1
 
|-
 
|-
|Oxacillin
+
|[[Oxacillin]]
 
|1
 
|1
 
|0
 
|0
Line 70: Line 75:
 
|1
 
|1
 
|-
 
|-
|Amoxicillin
+
|[[Amoxicillin]]
 
|0
 
|0
 
|1
 
|1
Line 87: Line 92:
 
|2
 
|2
 
|-
 
|-
|Ampicillin
+
|[[Ampicillin]]
 
|0
 
|0
 
|1
 
|1
Line 104: Line 109:
 
|2
 
|2
 
|-
 
|-
|Cephalexin
+
|[[Cephalexin]]
 
|1
 
|1
 
|0
 
|0
Line 121: Line 126:
 
|2
 
|2
 
|-
 
|-
|Erythromycin
+
|[[Erythromycin]]
 
|0
 
|0
 
|0
 
|0
Line 138: Line 143:
 
|2
 
|2
 
|-
 
|-
|Erythromycin
+
|[[Erythromycin]]
 
|0
 
|0
 
|0
 
|0
Line 155: Line 160:
 
|2
 
|2
 
|-
 
|-
|Metronidazole
+
|[[Metronidazole]]
 
|0
 
|0
 
|0
 
|0
Line 172: Line 177:
 
|2
 
|2
 
|-
 
|-
|Penicillin
+
|[[Penicillin]]
 
|0
 
|0
 
|1
 
|1
Line 189: Line 194:
 
|2
 
|2
 
|-
 
|-
|Aztreonam
+
|[[Aztreonam]]
 
|0
 
|0
 
|0
 
|0
Line 206: Line 211:
 
|3
 
|3
 
|-
 
|-
|Cefazolin
+
|[[Cefazolin]]
 
|1
 
|1
 
|0
 
|0
Line 223: Line 228:
 
|3
 
|3
 
|-
 
|-
|Cefdinir
+
|[[Cefdinir]]
 
|1
 
|1
 
|0
 
|0
Line 240: Line 245:
 
|3
 
|3
 
|-
 
|-
|Cefixime
+
|[[Cefixime]]
 
|0
 
|0
 
|0
 
|0
Line 257: Line 262:
 
|3
 
|3
 
|-
 
|-
|Cefpodoxime
+
|[[Cefpodoxime]]
 
|1
 
|1
 
|0
 
|0
Line 274: Line 279:
 
|3
 
|3
 
|-
 
|-
|Rifampin
+
|[[Rifampin]]
 
|1
 
|1
 
|0
 
|0
Line 291: Line 296:
 
|3
 
|3
 
|-
 
|-
|Azithromycin
+
|[[Azithromycin]]
 
|1
 
|1
 
|0
 
|0
Line 308: Line 313:
 
|4
 
|4
 
|-
 
|-
|Cefprozil
+
|[[Cefprozil]]
 
|1
 
|1
 
|0
 
|0
Line 325: Line 330:
 
|4
 
|4
 
|-
 
|-
|Ceftazidime
+
|[[Ceftazidime]]
 
|0
 
|0
 
|0
 
|0
Line 342: Line 347:
 
|4
 
|4
 
|-
 
|-
|Cefuroxime
+
|[[Cefuroxime]]
 
|1
 
|1
 
|0
 
|0
Line 359: Line 364:
 
|4
 
|4
 
|-
 
|-
|Chloramphenicol
+
|[[Chloramphenicol]]
 
|0
 
|0
 
|0
 
|0
Line 376: Line 381:
 
|4
 
|4
 
|-
 
|-
|Clarithromycin
+
|[[Clarithromycin]]
 
|1
 
|1
 
|0
 
|0
Line 393: Line 398:
 
|4
 
|4
 
|-
 
|-
|Clindamycin
+
|[[Clindamycin]]
 
|1
 
|1
 
|0
 
|0
Line 410: Line 415:
 
|4
 
|4
 
|-
 
|-
|Piperacillin
+
|[[Piperacillin]]
 
|0
 
|0
 
|1
 
|1
Line 427: Line 432:
 
|4
 
|4
 
|-
 
|-
  +
|[[TMP-SMX]]
|Trimethoprim- sulfamethoxazole
 
 
|1
 
|1
 
|0
 
|0
Line 444: Line 449:
 
|4
 
|4
 
|-
 
|-
|Cefotaxime
+
|[[Cefotaxime]]
 
|1
 
|1
 
|0
 
|0
Line 461: Line 466:
 
|5
 
|5
 
|-
 
|-
|Cefoxitin
+
|[[Cefoxitin]]
 
|1
 
|1
 
|0
 
|0
Line 478: Line 483:
 
|5
 
|5
 
|-
 
|-
|Ceftriaxone
+
|[[Ceftriaxone]]
 
|1
 
|1
 
|0
 
|0
Line 495: Line 500:
 
|5
 
|5
 
|-
 
|-
  +
|[[Colistin]]
|Colistimethate
 
 
|0
 
|0
 
|0
 
|0
Line 512: Line 517:
 
|5
 
|5
 
|-
 
|-
|Daptomycin
+
|[[Daptomycin]]
 
|1
 
|1
 
|1
 
|1
Line 529: Line 534:
 
|5
 
|5
 
|-
 
|-
|Doxycycline
+
|[[Doxycycline]]
 
|1
 
|1
 
|0
 
|0
Line 546: Line 551:
 
|5
 
|5
 
|-
 
|-
|Gentamicin
+
|[[Gentamicin]]
 
|1
 
|1
 
|0
 
|0
Line 563: Line 568:
 
|5
 
|5
 
|-
 
|-
|Minocycline
+
|[[Minocycline]]
 
|1
 
|1
 
|0
 
|0
Line 580: Line 585:
 
|5
 
|5
 
|-
 
|-
|Telavancin
+
|[[Telavancin]]
 
|1
 
|1
 
|1
 
|1
Line 597: Line 602:
 
|5
 
|5
 
|-
 
|-
|Tobramycin
+
|[[Tobramycin]]
 
|1
 
|1
 
|0
 
|0
Line 614: Line 619:
 
|5
 
|5
 
|-
 
|-
|Vancomycin
+
|[[Vancomycin]]
 
|1
 
|1
 
|1
 
|1
Line 631: Line 636:
 
|5
 
|5
 
|-
 
|-
|Amikacin sulfate
+
|[[Amikacin]]
 
|1
 
|1
 
|0
 
|0
Line 648: Line 653:
 
|6
 
|6
 
|-
 
|-
|Amoxicillin-clavulanate
+
|[[Amoxicillin-clavulanic acid]]
 
|1
 
|1
 
|1
 
|1
Line 665: Line 670:
 
|6
 
|6
 
|-
 
|-
|Ampicillin-sulbactam
+
|[[Ampicillin-sulbactam]]
 
|1
 
|1
 
|1
 
|1
Line 682: Line 687:
 
|6
 
|6
 
|-
 
|-
|Cefepime
+
|[[Cefepime]]
 
|1
 
|1
 
|0
 
|0
Line 699: Line 704:
 
|6
 
|6
 
|-
 
|-
|Linezolid
+
|[[Linezolid]]
 
|1
 
|1
 
|1
 
|1
Line 716: Line 721:
 
|6
 
|6
 
|-
 
|-
|Ticarcillin-clavulanate
+
|[[Ticarcillin-clavulanate]]
 
|1
 
|1
 
|0
 
|0
Line 733: Line 738:
 
|6
 
|6
 
|-
 
|-
|Ceftaroline
+
|[[Ceftaroline]]
 
|1
 
|1
 
|1
 
|1
Line 750: Line 755:
 
|8
 
|8
 
|-
 
|-
|Ciprofloxacin
+
|[[Ciprofloxacin]]
 
|1
 
|1
 
|1
 
|1
Line 767: Line 772:
 
|8
 
|8
 
|-
 
|-
|Piperacillin-tazobactam
+
|[[Piperacillin-tazobactam]]
 
|1
 
|1
 
|1
 
|1
Line 784: Line 789:
 
|8
 
|8
 
|-
 
|-
|Ertapenem
+
|[[Ertapenem]]
 
|1
 
|1
 
|0
 
|0
Line 801: Line 806:
 
|9
 
|9
 
|-
 
|-
|Levofloxacin
+
|[[Levofloxacin]]
 
|1
 
|1
 
|1
 
|1
Line 818: Line 823:
 
|9
 
|9
 
|-
 
|-
|Meropenem
+
|[[Meropenem]]
 
|1
 
|1
 
|0
 
|0
Line 835: Line 840:
 
|10
 
|10
 
|-
 
|-
|Moxifloxacin
+
|[[Moxifloxacin]]
 
|1
 
|1
 
|1
 
|1
Line 852: Line 857:
 
|10
 
|10
 
|-
 
|-
|Imipenem-cilastatin
+
|[[Imipenem-cilastatin]]
 
|1
 
|1
 
|1
 
|1
Line 869: Line 874:
 
|11
 
|11
 
|-
 
|-
|Tigecycline
+
|[[Tigecycline]]
 
|1
 
|1
 
|1
 
|1
Line 886: Line 891:
 
|13
 
|13
 
|}
 
|}
  +
MSSA = methicillin-susceptible [[Staphylococcus aureus]]; E/K = [[Escherichia coli]]/[[Klebsiella]]; M/H.flu = [[Moraxella]] and [[Haemophilus influenzae]]; Pseudo = [[Pseudomonas aeruginosa]]; MRSA = [[methicillin-resistant Staphylococcus aureus]]; PRP = penicillin-resistant [[pneumococcus]]; VRE = vancomycin-resistant [[Enterococcus]]; atypicals = [[Mycoplasma pneumoniae]] and [[Chlamidophila]]; MDRO = multidrug-resistant organisms
   
 
==Further Reading==
 
==Further Reading==

Latest revision as of 14:34, 4 April 2024

Working Ranking

Sample Spectrum Index

Antibiotic MSSA E.faeca Anaerobes Bacteroides M/H.flu E/K AmpC ESBL Pseudo MRSA PRP VRE Atypicals MDRO ASI
Dicloxacillin 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Oxacillin 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Amoxicillin 0 1 0 0 0 1 0 0 0 0 0 0 0 0 2
Ampicillin 0 1 0 0 0 1 0 0 0 0 0 0 0 0 2
Cephalexin 1 0 0 0 0 1 0 0 0 0 0 0 0 0 2
Erythromycin 0 0 0 0 1 0 0 0 0 0 0 0 1 0 2
Erythromycin 0 0 0 0 1 0 0 0 0 0 0 0 1 0 2
Metronidazole 0 0 1 1 0 0 0 0 0 0 0 0 0 0 2
Penicillin 0 1 1 0 0 0 0 0 0 0 0 0 0 0 2
Aztreonam 0 0 0 0 1 1 0 0 1 0 0 0 0 0 3
Cefazolin 1 0 0 0 1 1 0 0 0 0 0 0 0 0 3
Cefdinir 1 0 0 0 1 1 0 0 0 0 0 0 0 0 3
Cefixime 0 0 1 0 1 1 0 0 0 0 0 0 0 0 3
Cefpodoxime 1 0 0 0 1 1 0 0 0 0 0 0 0 0 3
Rifampin 1 0 0 0 1 0 0 0 0 1 0 0 0 0 3
Azithromycin 1 0 1 0 1 0 0 0 0 0 0 0 1 0 4
Cefprozil 1 0 1 0 1 1 0 0 0 0 0 0 0 0 4
Ceftazidime 0 0 1 0 1 1 0 0 1 0 0 0 0 0 4
Cefuroxime 1 0 1 0 1 1 0 0 0 0 0 0 0 0 4
Chloramphenicol 0 0 1 1 1 1 0 0 0 0 0 0 0 0 4
Clarithromycin 1 0 1 0 1 0 0 0 0 0 0 0 1 0 4
Clindamycin 1 0 1 1 0 0 0 0 0 1 0 0 0 0 4
Piperacillin 0 1 1 0 0 1 0 0 1 0 0 0 0 0 4
TMP-SMX 1 0 0 0 1 1 0 0 0 1 0 0 0 0 4
Cefotaxime 1 0 1 0 1 1 0 0 0 0 1 0 0 0 5
Cefoxitin 1 0 1 1 1 1 0 0 0 0 0 0 0 0 5
Ceftriaxone 1 0 1 0 1 1 0 0 0 0 1 0 0 0 5
Colistin 0 0 0 0 0 1 1 1 1 0 0 0 0 1 5
Daptomycin 1 1 0 0 0 0 0 0 0 1 0 1 0 1 5
Doxycycline 1 0 0 0 1 1 0 0 0 1 0 0 1 0 5
Gentamicin 1 0 0 0 1 1 0 0 1 1 0 0 0 0 5
Minocycline 1 0 0 0 1 1 0 0 0 1 0 0 1 0 5
Telavancin 1 1 0 0 0 0 0 0 0 1 1 0 0 1 5
Tobramycin 1 0 0 0 1 1 0 0 1 1 0 0 0 0 5
Vancomycin 1 1 0 0 0 0 0 0 0 1 1 0 0 1 5
Amikacin 1 0 0 0 1 1 0 0 1 1 0 0 0 1 6
Amoxicillin-clavulanic acid 1 1 1 1 1 1 0 0 0 0 0 0 0 0 6
Ampicillin-sulbactam 1 1 1 1 1 1 0 0 0 0 0 0 0 0 6
Cefepime 1 0 0 0 1 1 1 0 1 0 1 0 0 0 6
Linezolid 1 1 0 0 0 0 0 0 0 1 1 1 0 1 6
Ticarcillin-clavulanate 1 0 1 1 1 1 0 0 1 0 0 0 0 0 6
Ceftaroline 1 1 0 0 1 1 1 0 0 1 1 0 0 1 8
Ciprofloxacin 1 1 0 0 1 1 1 1 1 0 0 0 1 0 8
Piperacillin-tazobactam 1 1 1 1 1 1 1 0 1 0 0 0 0 0 8
Ertapenem 1 0 1 1 1 1 1 1 0 0 1 0 0 1 9
Levofloxacin 1 1 1 0 1 1 1 1 0 0 1 0 1 0 9
Meropenem 1 0 1 1 1 1 1 1 1 0 1 0 0 1 10
Moxifloxacin 1 1 1 1 1 1 1 0 0 1 1 0 1 0 10
Imipenem-cilastatin 1 1 1 1 1 1 1 1 1 0 1 0 0 1 11
Tigecycline 1 1 1 1 1 1 1 1 0 1 1 1 1 1 13

MSSA = methicillin-susceptible Staphylococcus aureus; E/K = Escherichia coli/Klebsiella; M/H.flu = Moraxella and Haemophilus influenzae; Pseudo = Pseudomonas aeruginosa; MRSA = methicillin-resistant Staphylococcus aureus; PRP = penicillin-resistant pneumococcus; VRE = vancomycin-resistant Enterococcus; atypicals = Mycoplasma pneumoniae and Chlamidophila; MDRO = multidrug-resistant organisms

Further Reading

  • Development and Application of an Antibiotic Spectrum Index for Benchmarking Antibiotic Selection Patterns Across Hospitals. Infect Control Hosp Epidemiol. 2017;38(8):993-997. doi: 10.1017/ice.2017.94.