Meropenem-vaborbactam
From IDWiki
Background
Mechanism of Activity
- Vaborbactam is active against KPC carbapenemases
Dosing
- Carbapenem-resistant infection with Enterobacterales: 4 g IV every 8 hours
- Complicated urinary tract infection: 4 g IV every 8 hours for 5 to 14 days
Renal Dosing
| eGFR | Dose |
|---|---|
| ≥50 | 4 g IV every 8 hours (normal dose) |
| 30 to 49 | 2 g IV every 8 hours |
| 15 to 29 | 2 g IV every 12 hours |
| <15 | 1 g IV every 12 hours |
| IHD | 1 g IV every 12 hours |
| PD | 1 g IV every 12 hours |
| CRRT | 2 g IV every 8 hours |
Safety
Monitoring
- Seizures, thrombocytopenia, drug interaction with valproic acid
