Protozoa

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Group Organism Common Name Exposure Treatment
Amoebae
obligate amoebae Entamoeba histolytica amebic dysentery iodoquinol or paramomycin or metronidazole or tinidazole
Blastocystis hominis metronidazole or TMP-SMX or iodoquinol
free-living amoebae Naegleria fowleri primary amebic meningoencephalitis warm freshwater combination therapy
Balamuthia mandrillaris granulomatous amebic encephalitis warm freshwater combination therapy
Acanthamoeba granulomatous amebic encephalitis and amebic keratitis warm freshwater combination therapy
Flagellates
kinetoplastid flagellates Trypanosoma cruzi Chagas disease benznidazole or nifurtimox
Trypanosoma brucei African sleeping sickess individualized
Leishmania leishmaniasis individualized
intestinal flagellates Giardia lamblia giardiasis tinidazole or metronidazole or nitazoxanide
Dientamoeba fragilis paromomycin or iodoquinol or metronidazole
genitourinary flagellates Trichomonas vaginalis trichomoniasis tinidazole or metronidazole
Apicomplexa
Haemosporida Plasmodium falciparum malaria atovaquone-proguanil or artesunate if severe
Other Plasmodium malaria quinine + doxycycline ± primaquine
Babesia babesiosis atovaquone + azithromycin
blood and tissue coccidia Toxoplasma gondii toxoplasmosis eating undercooked meat or cat feces pyrimethamine + sulfadiazine
Sarcocystis sarcocystosis eating undercooked meat possibly albendazole
gut coccidia Cryptosporidium cryptosporidiosis nitazoxanide
Cyclospora cayetanensis cyclosporiasis TMP-SMX
Cystoisospora belli cystoisoporiasis TMP-SMX
Sarcocystis sarcocystosis possibly albendazole
Ciliates
gut ciliates Balantidium coli balantidiasis tetracycline