Background
- Hypersplenism is defined as splenomegaly with any of: anemia, leukopenia, or thrombocytopenia, which are expected to correct after splenectomy
- All patients with hypersplenism have splenomegaly, but not all patients with splenomegaly have hypersplenism
- Mostly secondary to other process, but rarely can be primary
Differential Diagnosis
- See also massive splenomegaly
- Infectious
- Acute
- Subacute or chronic
- Subacute bacterial endocarditis
- Tuberculosis
- Malaria
- Visceral leishmaniasis
- Fungal infections
- Inflammatory
- Congestive
- Hematologic
- Genetic/metabolic
- Other
