Serum sickness
From IDWiki
Clinical Manifestations
- Onset within 1 to 2 weeks of exposure
- Fever (> 38.5 Celsius) in almost all patients, often spiking high then normalizing within the same day, without predictable pattern
- Rash in almost all patients, which can be variable, but most commonly includes a pruritic rash (often as the earliest symptom), ad lasts days to a few weeks after cessation of the exposure
- Often starts at the site of inoculation
- Does not typically involve mucosal membranes
- May include urticaria with individual lesions lasting days to weeks rather than coming and going like hives
- Can occasionally include palpable purpura, morbilliform rashes, papular or maculopapular lesions
- Arthralgias in about 2/3 of patients, involving large and small joints
- Also: headache, blurred vision, edema, lymphadenopathy, splenomegaly, GI symptoms, anterior uveitis, peripheral neuropathy (including Guillain-Barré syndrome), nephropathy (including glomerulonephritis), and vasculitis
