Infectious mononucleosis
From IDWiki
Background
Microbiology
- Epstein-Barr virus (80%)
- Cytomegalovirus (20%)
Clinical Manifestations
- Syndrome of sore throat, fever, and lymphadenopathy
- EBV-associated mono is the most common; see Epstein-Barr virus for more details
- CMV-associated mono is usually milder than EBV, with less prominent lymphadenopathy but almost always with hepatitis
Differential Diagnosis
- Acute HIV infection, which more commonly has mucocutaneous ulcerations and a rash
- Toxoplasmosis, which usually does not have pharyngitis or hepatitis
- Acute HHV-6 and HHV-7
Investigations
- Patients with negative heterophile antibody testing for EBV should have an HIV test
Management
- Generally supportive care
