Thrombotic microangiopathy
From IDWiki
- Syndrome of microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis leading to organ dysfunction
Disease | Clinical Clues |
---|---|
Primary | |
Thrombotic thrombocytopenia purpura | PT/INR and PTT are normal |
Hemolytic-uremic syndrome | PT/INR and PTT are normal, severe AKI |
Atypical hemolytic-uremic syndrome | PT/INR and PTT are normal, severe AKI |
HELLP syndrome | pregnancy |
Secondary | |
Autoimmune disease, including systemic lupus erythematosus or antiphospholid antibody syndrome | |
Drug-induced thrombotic microangiopathy | including quinine, ticlopidine, and chemotherapy (mitomycin, gemcitabine, cyclosporine, and tacrolimus, though it may also be caused by the underlying condition |
Sepsis | |
Secondary hemolytic-uremic syndrome | most commonly from Streptococcus pneumoniae or influenza |
DIC | PT/INR and PTT are prolonged |
Malignancy | |
HIV |