Cladophialophora species
From IDWiki
Background
- Includes Cladophialophora bantiana and Cladophialophora modesta, which are neurotropic and cause CNS disease
- Other Cladophialophora species may cause mild cutaneous lesions to disseminated disease.
Epidemiology
- More common in India
Diagnosis
- Culture
- Microscopy
- Long, delicate, branching chains of hydrophobic brown conidia and lacking yeast cells, with brown septate hyphae
- The species (and Cladosporium) are differentiated by physiologic tests include temperature tolerance, gelatin liquefaction, cycloheximide growth, urease test, and the nitrate test
- Microscopy
- Histopathology is necessary for subcutaneous infections
Management
- Surgical resection is recommended when possible
- CNS disease may not respond to antifungal therapy
- Amphotericin B, flucytosine, caspofungin and terbinafine, or an extended spectrum triazole may be tried when surgical resection is not possible
- For Cladophialophora bantiana infections, the combination of the three drugs (flucytosine, micafungin and posaconazole) is recommended based on a mouse model1
References
- ^ Marçal Mariné, F. Javier Pastor, Josep Guarro. Combined antifungal therapy in a murine model of disseminated infection byCladophialophora bantiana. Medical Mycology. 2009;47(1):45-49. doi:10.1080/13693780802526840.
