Diabetic foot infection

Background

Microbiology

• Typically polymicrobial, including:
  • Staphylococcus aureus, which is by far the most common cause of monomicrobial infections
  • Coagulase-negative staphylococci
  • Streptococcus species
  • ENterococcus species
  • Enterobacteriaceae
  • Pseudomonas aeruginosa
  • Anaerobes, including Bacteroides fragilis
• Anaerobes are more likely to be involved in deeper, more chronic ulcers

Diagnosis

• Osteomyelitis should be considered in all cases of diabetic foot infection
  • Probe-to-bone test should be done routinely
  • Plain film X-ray can be helpful, though not sensitive
  • MRI is the preferred diagnostic test, followed by bone and white cell scan
  • The gold standard is still bone biopsy for histopathology and culture

Management

Severity	Common Pathogens	Antibiotics	Notes
Mild	methicillin-susceptible Staphylococcus aureus, Streptococcus species	dicloxacillin	qid dosing and very narrow-spectrum
		clindamycin	active against MRSA but higher risk of CDAD
		cephalexin	qid dosing
		levofloxacin	not as effective against Staphylococcus aureus
		amoxicillin-clavulanic acid	broad-spectrum, includes anaerobic coverage
	methicillin-resistant Staphylococcus aureus	doxycycline	uncertain activity against streptococci
		TMP-SMX	uncertain activity against streptococci
moderate or severe	MSSA, Streptococcus species, Enterobacteriaceae, anaerobes	levofloxacin	suboptimal against MSSA
		cefoxitin
		ceftriaxone
		ampicillin-sulbactam
		moxifloxacin
		ertapenem
		tigecycline
		fluoroquinolone with clindamycin
		imipenem-cilastatin
	MRSA	linezolid
		daptomycin
		vancomycin
	Pseudomonas aeruginosa	piperacillin-tazobactam

Duration

• After amputation or resection
  • If good source control, only 2 to 5 days is recommended
  • If there is persistent infection or necrotic bone, 4 or more weeks
• Osteomyelitis
  • Traditionally, 6 weeks of parenteral therapy
  • May be able to shorten to 3 weeks if adequately debrided, based on more recent evidence1

Further Reading

• The Neuropathic Diabetic Foot Ulcer Microbiome IsAssociated With Clinical Factors. Diabetes. 2013;62:923-930.