Protozoa

Group	Organism	Common Name	Exposure	Treatment
Amoebae
obligate amoebae	Entamoeba histolytica	amebic dysentery		iodoquinol or paramomycin or metronidazole or tinidazole
	Blastocystis hominis			metronidazole or TMP-SMX or iodoquinol
free-living amoebae	Naegleria fowleri	primary amebic meningoencephalitis	warm freshwater	combination therapy
	Balamuthia mandrillaris	granulomatous amebic encephalitis	warm freshwater	combination therapy
	Acanthamoeba species	granulomatous amebic encephalitis and amebic keratitis	warm freshwater	combination therapy
Flagellates
kinetoplastid flagellates	Trypanosoma cruzi	Chagas disease		benznidazole or nifurtimox
	Trypanosoma brucei	African sleeping sickess		individualized
	Leishmania species	leishmaniasis		individualized
intestinal flagellates	Giardia lamblia	giardiasis		tinidazole or metronidazole or nitazoxanide
	Dientamoeba fragilis			paromomycin or iodoquinol or metronidazole
genitourinary flagellates	Trichomonas vaginalis	trichomoniasis		tinidazole or metronidazole
Apicomplexa
Haemosporida	Plasmodium falciparum	malaria		atovaquone-proguanil or artesunate if severe
	Other Plasmodium species	malaria		quinine + doxycycline ± primaquine
	Babesia species	babesiosis		atovaquone + azithromycin
blood and tissue coccidia	Toxoplasma gondii	toxoplasmosis	eating undercooked meat or cat feces	pyrimethamine + sulfadiazine
	Sarcocystis species	sarcocystosis	eating undercooked meat	possibly albendazole
gut coccidia	Cryptosporidium species	cryptosporidiosis		nitazoxanide
	Cyclospora cayetanensis	cyclosporiasis		TMP-SMX
	Cystoisospora belli	cystoisoporiasis		TMP-SMX
	Sarcocystis species	sarcocystosis		possibly albendazole
Ciliates
gut ciliates	Balantidium coli	balantidiasis		tetracycline