Antifungal spectrum of activity: Difference between revisions

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{| class="wikitable"
{| class="wikitable"
! Organism
! rowspan="2" |Organism
!align="center"| [[Amphotericin B|AmB]]
! rowspan="2" |[[Amphotericin B|AmB]]
! colspan="4" |Triazoles
⚫
!align="center"| [[Fluconazole|Fluc]]
! colspan="3" |Echinocandins
⚫
!align="center"| [[Itraconazole|Itra]]
!align="center"| [[Voriconazole|Vori]]
! rowspan="2" |[[Flucytasine|Flucyt]]
⚫
!align="center"| [[Posaconazole|Posa]]
⚫
!align="center"| [[Anidulafungin|Anidula]]
⚫
!align="center"| [[Caspofungin|Caspo]]
⚫
!align="center"| [[Micafungin|Mica]]
⚫
!align="center"| [[Flucytasine|Flucyt]]
|-
|-
⚫
! align="center" |[[Fluconazole|Fluc]]
⚫
| [[Aspergillus species]]
⚫
! align="center" |[[Itraconazole|Itra]]
⚫
! align="center" |[[Voriconazole|Vori]]
⚫
! align="center" |[[Posaconazole|Posa]]
⚫
! align="center" |[[Anidulafungin|Anidula]]
⚫
! align="center" |[[Caspofungin|Caspo]]
⚫
! align="center" |[[Micafungin|Mica]]
|-
⚫
|[[Aspergillus species]]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
|  [[Aspergillus flavus|''A. flavus'']]
| [[Aspergillus flavus|''A. flavus'']]
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
|  [[Aspergillus fumigatus|''A. fumigatus'']]
| [[Aspergillus fumigatus|''A. fumigatus'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
|  [[Aspergillus terreus|''A. terreus'']]
| [[Aspergillus terreus|''A. terreus'']]
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
|  [[Aspergillus niger|''A. niger'']]
| [[Aspergillus niger|''A. niger'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
| [[Candida species]]
|[[Candida species]]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  [[Candida albicans|''C. albicans'']]
| [[Candida albicans|''C. albicans'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  [[Candida glabrata|''C. glabrata'']]
| [[Candida glabrata|''C. glabrata'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  [[Candida krusei|''C. krusei'']]
| [[Candida krusei|''C. krusei'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
|-
|-
|  [[Candida lusitaniae|''C. lusitaniae'']]
| [[Candida lusitaniae|''C. lusitaniae'']]
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  [[Candida parapsilosis|''C. parapsilosis'']]
| [[Candida parapsilosis|''C. parapsilosis'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  [[Candida tropicalis|''C. tropicalis'']]
| [[Candida tropicalis|''C. tropicalis'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
| [[Cryptococcus neoformans]]
|[[Cryptococcus neoformans]]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
| [[Coccidioides imitis|''Coccidioides'']]
|[[Coccidioides imitis|''Coccidioides'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
| [[Blastomyces dermatitidis|''Blastomyces'']]
|[[Blastomyces dermatitidis|''Blastomyces'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
| [[Histoplasma capsulatum|''Histoplasma'']]
|[[Histoplasma capsulatum|''Histoplasma'']]
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
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| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
| [[Fusarium species]]
|[[Fusarium species]]
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
| ''[[Scedosporium apiospermum]]''
|''[[Scedosporium apiospermum]]''
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
| ''[[Scedosporium prolificans]]''
|''[[Scedosporium prolificans]]''
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|-
|-
| [[Zygomycetes]]
|[[Zygomycetes]]
| style="text-align:center;background-color:lemonchiffon" | ±
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" | –
| style="text-align:center;background-color:indianred" |–
|}
|}


''Aspergillus ustus'' is resistant to azoles and echinocandins, and variable resistance to amphotericin (though still susceptible to terbinafine)
* [[Aspergillus ustus]] is resistant to azoles and echinocandins, and variable resistance to [[amphotericin]] (though still susceptible to [[terbinafine]])


'''Source:''' Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, [https://doi.org/10.1086/504492 https://doi.org/10.1086/504492]
'''Source:''' Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492


[[Category:Antifungals]]
[[Category:Antifungals]]

Revision as of 11:05, 26 August 2020

Organism AmB Triazoles Echinocandins Flucyt
Fluc Itra Vori Posa Anidula Caspo Mica
Aspergillus species + – + + + + + + –
 A. flavus ± – + + + + + + –
 A. fumigatus + – + + + + + + –
 A. terreus – – + + + + + + –
 A. niger + – ± + + + + + –
Candida species + + + + + + + + +
 C. albicans + + + + + + + + +
 C. glabrata + ± ± + + + + + +
 C. krusei + – ± + + + + + ±
 C. lusitaniae – + + + + + + + +
 C. parapsilosis + + + + + ± ± ± +
 C. tropicalis + + + + + + + + +
Cryptococcus neoformans + + + + + – – – +
Coccidioides + + + + + ± ± ± –
Blastomyces + + + + + ± ± ± –
Histoplasma + + + + + ± ± ± –
Fusarium species ± – – + + – – – –
Scedosporium apiospermum ± – ± + + – – – –
Scedosporium prolificans – – – ± ± – – – –
Zygomycetes ± – – – + – – – –

Source: Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492

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