Thrombotic microangiopathy: Difference between revisions
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*Syndrome of [[microangiopathic hemolytic anemia]], [[thrombocytopenia]], and microvascular thrombosis leading to organ dysfunction |
*Syndrome of [[microangiopathic hemolytic anemia]], [[thrombocytopenia]], and microvascular thrombosis leading to organ dysfunction |
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+ | {| class="wikitable" |
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− | *Primary |
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+ | !Disease |
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+ | !Clinical Clues |
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+ | |- |
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+ | ! colspan="2" |Primary |
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+ | |- |
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− | *Associated with coexisting condition |
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+ | |PT/INR and PTT are normal |
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+ | |- |
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⚫ | |||
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+ | |PT/INR and PTT are normal |
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⚫ | |||
+ | |- |
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⚫ | |||
− | |||
+ | |PT/INR and PTT are normal |
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+ | |- |
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+ | | |
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+ | |- |
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+ | ! colspan="2" |Secondary |
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+ | |- |
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+ | | |
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+ | |- |
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+ | |[[Drug-induced thrombotic microangiopathy]] |
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+ | |- |
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+ | |[[Sepsis]] |
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+ | | |
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+ | |- |
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+ | |[[Secondary hemolytic-uremic syndrome]] |
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⚫ | |||
+ | |- |
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+ | |PT/INR and PTT are prolonged |
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+ | |- |
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+ | | |
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+ | |- |
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+ | | |
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+ | |} |
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[[Category:Hematology]] |
[[Category:Hematology]] |
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[[Category:Thrombosis]] |
[[Category:Thrombosis]] |
Revision as of 07:25, 19 March 2024
- Syndrome of microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis leading to organ dysfunction
Disease | Clinical Clues |
---|---|
Primary | |
Thrombotic thrombocytopenia purpura | PT/INR and PTT are normal |
Hemolytic-uremic syndrome | PT/INR and PTT are normal |
Atypical hemolytic-uremic syndrome | PT/INR and PTT are normal |
HELLP syndrome | |
Secondary | |
Autoimmune disease, including systemic lupus erythematosus or antiphospholid antibody syndrome | |
Drug-induced thrombotic microangiopathy | including quinine, ticlopidine, and chemotherapy (mitomycin, gemcitabine, cyclosporine, and tacrolimus, though it may also be caused by the underlying condition |
Sepsis | |
Secondary hemolytic-uremic syndrome | most commonly from Streptococcus pneumoniae or influenza |
DIC | PT/INR and PTT are prolonged |
Malignancy | |
HIV |