Antifungal spectrum of activity: Difference between revisions

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{| class="wikitable"
= Antifungal spectrum =
! rowspan="2" |Organism

! rowspan="2" |[[Amphotericin B|AmB]]
{|
! colspan="4" |Triazoles
! Organism
! colspan="3" |Echinocandins
!align="center"| AmB
! rowspan="2" |[[Flucytasine|Flucyt]]
!align="center"| Fluc
!align="center"| Itra
!align="center"| Vori
!align="center"| Posa
!align="center"| Anidula
!align="center"| Caspo
!align="center"| Mica
!align="center"| Flucyt
|-
|-
! align="center" |[[Fluconazole|Fluc]]
| ''Aspergillus'' spp.
|align="center"| +
! align="center" |[[Itraconazole|Itra]]
|align="center"| –
! align="center" |[[Voriconazole|Vori]]
|align="center"| +
! align="center" |[[Posaconazole|Posa]]
|align="center"| +
! align="center" |[[Anidulafungin|Anidula]]
|align="center"| +
! align="center" |[[Caspofungin|Caspo]]
|align="center"| +
! align="center" |[[Micafungin|Mica]]
|align="center"| +
|align="center"| +
|align="center"| –
|-
|-
|[[Aspergillus]]
|  ''A. flavus''
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
|  ''A. fumigatus''
| [[Aspergillus flavus|''A. flavus'']]
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
|  ''A. terreus''
| [[Aspergillus fumigatus|''A. fumigatus'']]
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
|  ''A. niger''
| [[Aspergillus terreus|''A. terreus'']]
| style="text-align:center;background-color:indianred" |–
|align="center"| +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
| [[Aspergillus niger|''A. niger'']]
| ''Candida'' spp.
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" |–
|align="center"| +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" |–
|align="center"| +
|-
|-
|[[Candida]]
|  ''C. albicans''
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. glabrata''
| [[Candida albicans|''C. albicans'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. krusei''
| [[Candida glabrata|''C. glabrata'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
|-
|-
|  ''C. lusitaniae''
| [[Candida krusei|''C. krusei'']]
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
|-
|-
|  ''C. parapsilosis''
| [[Candida lusitaniae|''C. lusitaniae'']]
| style="text-align:center;background-color:indianred" |–
|align="center"| +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|  ''C. tropicalis''
| [[Candida parapsilosis|''C. parapsilosis'']]
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
| [[Candida tropicalis|''C. tropicalis'']]
| ''Cryptococcus neoformans''
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|-
|-
|[[Cryptococcus neoformans]]
| ''Coccidioides'' spp.
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" |–
|align="center"| ±
| style="text-align:center;background-color:indianred" |–
|align="center"| ±
| style="text-align:center;background-color:indianred" |–
|align="center"| ±
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
|-
|-
|[[Coccidioides imitis|''Coccidioides'']]
| ''Blastomyces''
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
|[[Blastomyces dermatitidis|''Blastomyces'']]
| ''Histoplasma'' spp.
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
|[[Histoplasma capsulatum|''Histoplasma'']]
| ''Fusarium'' spp.
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
|[[Fusarium]]
| ''Scedosporium apiospermum''
|align="center"| ±
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" |–
|align="center"| ±
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| +
| style="text-align:center;background-color:lightgreen" | +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
| ''Scedosporium prolificans''
|''[[Scedosporium apiospermum]]''
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
|align="center"| –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
| style="text-align:center;background-color:lightgreen" | +
|align="center"| ±
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|-
|''[[Scedosporium prolificans]]''
| Zygomycetes
| style="text-align:center;background-color:indianred" |–
|align="center"| ±
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| –
| style="text-align:center;background-color:lemonchiffon" |±
|align="center"| +
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|align="center"| –
| style="text-align:center;background-color:indianred" |–
|-
|[[Zygomycetes]]
| style="text-align:center;background-color:lemonchiffon" |±
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:lightgreen" | +
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" |–
| style="text-align:center;background-color:indianred" |–
|}
|}


''Aspergillus ustus'' is resistant to azoles and echinocandins, and variable resistance to amphotericin (though still susceptible to terbinafine)
* [[Aspergillus ustus]] is resistant to azoles and echinocandins, and variable resistance to [[amphotericin]] (though still susceptible to [[terbinafine]])

'''Source:''' Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492


[[Category:Antifungals]]
Source: [https://doi.org/10.1086/504492 https://doi.org/10.1086/504492]

Latest revision as of 10:50, 1 February 2022

Organism AmB Triazoles Echinocandins Flucyt
Fluc Itra Vori Posa Anidula Caspo Mica
Aspergillus + – + + + + + + –
 A. flavus ± – + + + + + + –
 A. fumigatus + – + + + + + + –
 A. terreus – – + + + + + + –
 A. niger + – ± + + + + + –
Candida + + + + + + + + +
 C. albicans + + + + + + + + +
 C. glabrata + ± ± + + + + + +
 C. krusei + – ± + + + + + ±
 C. lusitaniae – + + + + + + + +
 C. parapsilosis + + + + + ± ± ± +
 C. tropicalis + + + + + + + + +
Cryptococcus neoformans + + + + + – – – +
Coccidioides + + + + + ± ± ± –
Blastomyces + + + + + ± ± ± –
Histoplasma + + + + + ± ± ± –
Fusarium ± – – + + – – – –
Scedosporium apiospermum ± – ± + + – – – –
Scedosporium prolificans – – – ± ± – – – –
Zygomycetes ± – – – + – – – –

Source: Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492

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