Secondary hemolytic-uremic syndrome: Difference between revisions
From IDWiki
(added C diff) |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 5: | Line 5: | ||
*Associated with autoimmune diseases, transplantation, malignancy, infection, cytotoxic mediation, or pregnancy |
*Associated with autoimmune diseases, transplantation, malignancy, infection, cytotoxic mediation, or pregnancy |
||
**Most common associations are with [[Streptococcus pneumoniae]] and [[influenza]] |
**Most common associations are with [[Streptococcus pneumoniae]] and [[influenza]] |
||
**Possibly acute [[Clostridioides difficile]][[CiteRef::keshtkar-jahromi2012he]][[CiteRef::khurshid2020at]][[CiteRef::alvarado2014he]] |
|||
**Possibly acute [[Clostridioides difficile]]<ref>Keshtkar-Jahromi M, Mohebtash M. Hemolytic uremic syndrome and Clostridium difficile colitis. J Community Hosp Intern Med Perspect. 2012 Oct 15;2(3). doi: [https://doi.org/10.3402/jchimp.v2i3.19064 10.3402/jchimp.v2i3.19064]. PMID: [https://pubmed.ncbi.nlm.nih.gov/23882375/ 23882375]; PMCID: [http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3714067/ PMC3714067].</ref><ref>Khurshid Q, Mahmoud A, Shahid M, Mohamed A, Shahbaz A. Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection. Cureus. 2020 Jul 5;12(7):e9005. doi: [https://doi.org/10.7759%2Fcureus.9005 10.7759/cureus.9005]. PMID: [https://pubmed.ncbi.nlm.nih.gov/32775085 32775085]; PMCID: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402547/ PMC7402547].</ref><ref>Alvarado AS, Brodsky SV, Nadasdy T, Singh N. Hemolytic uremic syndrome associated with Clostridium difficile infection. Clin Nephrol. 2014 Apr;81(4):302-6. doi: [https://doi.org/10.5414/cn107691 10.5414/CN107691]. PMID: [https://pubmed.ncbi.nlm.nih.gov/23320969/ 23320969].</ref> |
|||
**[[Solid organ transplantation]], mostly in the month or months after transplantation but rarely after a year |
**[[Solid organ transplantation]], mostly in the month or months after transplantation but rarely after a year[[CiteRef::caires2012de]] |
||
**[[Hematopoietic stem cell transplantation]], up to months to years after transplant |
**[[Hematopoietic stem cell transplantation]], up to months to years after transplant |
||
**[[Systemic lupus erythematosus]][[CiteRef::hughson1992re]] |
|||
**[[Systemic lupus erythematosus]]<ref>Hughson MD, Nadasdy T, McCarty GA, Sholer C, Min KW, Silva F. Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Kidney Dis. 1992 Aug;20(2):150-8. doi: [https://doi.org/10.1016/s0272-6386(12)80543-9 10.1016/s0272-6386(12)80543-9]. PMID: [[1496968]].</ref> |
|||
**Multiple solid organ malignancies (usually metastatic) are associated with [[TMA]], though prostate cancer (non-metastatic) appears to favour an HUS-like pattern |
**Multiple solid organ malignancies (usually metastatic) are associated with [[TMA]], though prostate cancer (non-metastatic) appears to favour an HUS-like pattern[[CiteRef::lechner2012ca]] |
||
**Normal [[pregnancy]][[CiteRef::egbor2011pr]] |
|||
**Normal [[pregnancy]]<ref>Egbor M, Johnson A, Harris F, Makanjoula D, Shehata H. Pregnancy-associated atypical haemolytic uraemic syndrome in the postpartum period: a case report and review of the literature. Obstet Med. 2011 Jun;4(2):83-5. doi: [https://doi.org/10.1258/om.2011.100059 10.1258/om.2011.100059]. Epub 2011 Jun 9. PMID: [https://pubmed.ncbi.nlm.nih.gov/27582861/ 27582861]; PMCID: PMC4989735.</ref> |
|||
**[[Drug-induced thrombotic microangiopathy]] |
**[[Drug-induced thrombotic microangiopathy]] |
||
[[Category:Thrombotic microangiopathies]] |
[[Category:Thrombotic microangiopathies]] |
||
Latest revision as of 16:43, 23 August 2024
Background
- One of the thrombotic microangiopathies
- Different pathophysiology and treatment from typical hemolytic-uremic syndrome (after STEC diarrhea) and atypical hemolytic-uremic syndrome (though often grouped with aHUS)
- Associated with autoimmune diseases, transplantation, malignancy, infection, cytotoxic mediation, or pregnancy
- Most common associations are with Streptococcus pneumoniae and influenza
- Possibly acute Clostridioides difficile123
- Solid organ transplantation, mostly in the month or months after transplantation but rarely after a year4
- Hematopoietic stem cell transplantation, up to months to years after transplant
- Systemic lupus erythematosus5
- Multiple solid organ malignancies (usually metastatic) are associated with TMA, though prostate cancer (non-metastatic) appears to favour an HUS-like pattern6
- Normal pregnancy7
- Drug-induced thrombotic microangiopathy
References
- ^ Maryam Keshtkar-Jahromi, Mahsa Mohebtash. Hemolytic uremic syndrome andClostridium difficilecolitis. Journal of Community Hospital Internal Medicine Perspectives. 2012;2(3):19064. doi:10.3402/jchimp.v2i3.19064.
- ^ Qasim Khurshid, Anas Mahmoud, Maria Shahid, Alaa Mohamed, Amir Shahbaz. Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection. Cureus. 2020. doi:10.7759/cureus.9005.
- ^ Anthony S. Alvarado, Sergey V. Brodsky, Tibor Nadasdy, Neeraj Singh. Hemolytic uremic syndrome associated with Clostridium difficile infection. Clinical Nephrology. 2014;81(04):302-306. doi:10.5414/cn107691.
- ^ R.A. Caires, I.D.B. Marques, L.P. Repizo, V.A.H. Sato, L.P.F. Carmo, D.J.B. Machado, F.J. de Paula, W.C. Nahas, E. David-Neto. De Novo Thrombotic Microangiopathy After Kidney Transplantation: Clinical Features, Treatment, and Long-Term Patient and Graft Survival. Transplantation Proceedings. 2012;44(8):2388-2390. doi:10.1016/j.transproceed.2012.07.039.
- ^ M.D. Hughson, T. Nadasdy, G.A. McCarty, C. Sholer, K-W. Min, F. Silva. Renal Thrombotic Microangiopathy in Patients With Systemic Lupus Erythematosus and the Antiphospholipid Syndrome. American Journal of Kidney Diseases. 1992;20(2):150-158. doi:10.1016/s0272-6386(12)80543-9.
- ^ Klaus Lechner, Hanna Lena Obermeier. Cancer-Related Microangiopathic Hemolytic Anemia. Medicine. 2012;91(4):195-205. doi:10.1097/md.0b013e3182603598.
- ^ M Egbor, A Johnson, F Harris, D Makanjoula, H Shehata. Pregnancy-associated atypical haemolytic uraemic syndrome in the postpartum period: a case report and review of the literature. Obstetric Medicine. 2011;4(2):83-85. doi:10.1258/om.2011.100059.
