Thrombotic microangiopathy: Difference between revisions

Latest revision as of 11:26, 19 March 2024

Syndrome of microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis leading to organ dysfunction

Disease	Clinical Clues
Primary
Thrombotic thrombocytopenia purpura	PT/INR and PTT are normal
Hemolytic-uremic syndrome	PT/INR and PTT are normal, severe AKI
Atypical hemolytic-uremic syndrome	PT/INR and PTT are normal, severe AKI
HELLP syndrome	pregnancy
Secondary
Autoimmune disease, including systemic lupus erythematosus or antiphospholid antibody syndrome
Drug-induced thrombotic microangiopathy	including quinine, ticlopidine, and chemotherapy (mitomycin, gemcitabine, cyclosporine, and tacrolimus, though it may also be caused by the underlying condition
Sepsis
Secondary hemolytic-uremic syndrome	most commonly from Streptococcus pneumoniae or influenza
DIC	PT/INR and PTT are prolonged
Malignancy
HIV

@@ Line 1: / Line 1: @@
 *Syndrome of [[microangiopathic hemolytic anemia]], [[thrombocytopenia]], and microvascular thrombosis leading to organ dysfunction
+{| class="wikitable"
-*Primary
+!Disease
-**[[Thrombotic thrombocytopenia purpura]]
+!Clinical Clues
-**[[Hemolytic-uremic syndrome]]
+|-
-**[[Atypical hemolytic-uremic syndrome]]
+! colspan="2" |Primary
-**[[HELLP syndrome]]
+|-
-*Associated with coexisting condition
+|[[Thrombotic thrombocytopenia purpura]]
-**Autoimmune disease, including [[systemic lupus erythematosus]] or [[antiphospholid antibody syndrome]]
+|PT/INR and PTT are normal
-**[[Drug-induced thrombotic microangiopathy]], including [[quinine]], [[ticlopidine]], and [[chemotherapy]] ([[mitomycin]], [[gemcitabine]], [[cyclosporine]], and [[tacrolimus]], though it may also be caused by the underlying condition)
+|-
-**[[Sepsis]] and [[secondary hemolytic-uremic syndrome]] (usually from [[Streptococcus pneumoniae]] or [[influenza]])
+|[[Hemolytic-uremic syndrome]]
-**[[DIC]]
+|PT/INR and PTT are normal, severe AKI
-**[[Malignancy]]
+|-
-**[[HIV]]
+|[[Atypical hemolytic-uremic syndrome]]
+|PT/INR and PTT are normal, severe AKI
+|-
+|[[HELLP syndrome]]
+|pregnancy
+|-
+! colspan="2" |Secondary
+|-
+|Autoimmune disease, including [[systemic lupus erythematosus]] or [[antiphospholid antibody syndrome]]
+|
+|-
+|[[Drug-induced thrombotic microangiopathy]]
+|including [[quinine]], [[ticlopidine]], and [[chemotherapy]] ([[mitomycin]], [[gemcitabine]], [[cyclosporine]], and [[tacrolimus]], though it may also be caused by the underlying condition
+|-
+|[[Sepsis]]
+|
+|-
+|[[Secondary hemolytic-uremic syndrome]]
+|most commonly from [[Streptococcus pneumoniae]] or [[influenza]]
+|-
+|[[DIC]]
+|PT/INR and PTT are prolonged
+|-
+|[[Malignancy]]
+|
+|-
+|[[HIV]]
+|
+|}
 [[Category:Hematology]]
 [[Category:Thrombosis]]