Thrombotic microangiopathy: Difference between revisions
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*Syndrome of [[microangiopathic hemolytic anemia]], [[thrombocytopenia]], and microvascular thrombosis leading to organ dysfunction |
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!Disease |
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!Clinical Clues |
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! colspan="2" |Primary |
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|PT/INR and PTT are normal |
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|PT/INR and PTT are normal, severe AKI |
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|PT/INR and PTT are normal, severe AKI |
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|[[HELLP syndrome]] |
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|pregnancy |
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! colspan="2" |Secondary |
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|Autoimmune disease, including [[systemic lupus erythematosus]] or [[antiphospholid antibody syndrome]] |
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|[[Drug-induced thrombotic microangiopathy]] |
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|including [[quinine]], [[ticlopidine]], and [[chemotherapy]] ([[mitomycin]], [[gemcitabine]], [[cyclosporine]], and [[tacrolimus]], though it may also be caused by the underlying condition |
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|[[Sepsis]] |
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|[[Secondary hemolytic-uremic syndrome]] |
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|most commonly from [[Streptococcus pneumoniae]] or [[influenza]] |
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|[[DIC]] |
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|PT/INR and PTT are prolonged |
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|[[Malignancy]] |
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|[[HIV]] |
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[[Category:Hematology]] |
[[Category:Hematology]] |
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[[Category:Thrombosis]] |
[[Category:Thrombosis]] |
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Latest revision as of 11:26, 19 March 2024
- Syndrome of microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis leading to organ dysfunction
| Disease | Clinical Clues |
|---|---|
| Primary | |
| Thrombotic thrombocytopenia purpura | PT/INR and PTT are normal |
| Hemolytic-uremic syndrome | PT/INR and PTT are normal, severe AKI |
| Atypical hemolytic-uremic syndrome | PT/INR and PTT are normal, severe AKI |
| HELLP syndrome | pregnancy |
| Secondary | |
| Autoimmune disease, including systemic lupus erythematosus or antiphospholid antibody syndrome | |
| Drug-induced thrombotic microangiopathy | including quinine, ticlopidine, and chemotherapy (mitomycin, gemcitabine, cyclosporine, and tacrolimus, though it may also be caused by the underlying condition |
| Sepsis | |
| Secondary hemolytic-uremic syndrome | most commonly from Streptococcus pneumoniae or influenza |
| DIC | PT/INR and PTT are prolonged |
| Malignancy | |
| HIV | |
