Itraconazole

Background

• Azole antifungal
• Indications include Alternaria, Blastomyces dermatitidis, Chromoblastomycosis, Coccidioides immitis, Cryptococcus, Entomophthoromycotina, Exophiala, Exserohilum, Fonsecaea, Histoplasma capsulatum, Mycetoma, Paracoccidioides brasiliensis, Sappinia diploidea, Sporothrix schenckii

Dosing

• Typical dose: 200 mg p.o. twice daily
• May be used once daily for the treatment of some dermatophytes

Safety

Therapeutic Drug Monitoring

• Should be measured 5 to 7 days after starting or changing the dose, or when interacting medications are changed
• Target in prophylaxis is a trough ot 0.5 mg/L
• Target in treatment is a trough >0.5 mg/L

Adverse Drug Reactions

• Headache
• Relative adrenal insufficiency
• Hepatotoxicity
• QTc prolongation