Exserohilum

From IDWiki
Exserohilum

Clinical Manifestations

  • Opportunistic pathogen in the immunocompromised, including aplastic anemia and HSCT
  • Causes keratitis, sinusitis, cutaneous, and subcutaneous infections
  • Of note, in 2012, it caused an outbreak of fungal meningitis associated with contaminated steroid injections (source was the compounding pharmacy)

Diagnosis

  • Culture
    • Colony: Growth is rapid and colonies are woolly and gray to black in color
    • Microscopy
      • Hyphae are septate and dematiaceous
      • Conidiophores are geniculate as a result of sympodial development
      • Conidia may be straight, curved or slightly bent and are distinguished by having prominent, protruding hila

Management

References

  1. ^  A. Katragkou, Z.-D. Pana, D. S. Perlin, D. P. Kontoyiannis, T. J. Walsh, E. Roilides. Exserohilum infections: Review of 48 cases before the 2012 United States outbreak. Medical Mycology. 2014;52(4):376-386. doi:10.1093/mmy/myt030.