Carbapenem-resistant organisms
From IDWiki
Background
- Mechanisms include decreased expression of porins, increased expression of efflux pumps, and carbapenemases
Management
Antibiotic | KPC | NDM | OXA-48 | CRPsA | CRAcB | Stenotrophomonas |
---|---|---|---|---|---|---|
aztreonam-avibactam | + | + | + | ± | – | + |
cefiderocol | + | + | + | + | + | + |
ceftazidime-avibactam | + | – | + | ± | – | – |
ceftolozane-tazobactam | – | – | – | ± | – | ± |
eravacycline | + | + | + | – | + | + |
fosfomycin | ± | ± | ± | ± | – | – |
imipenem-relebactam | + | – | ± | + | – | – |
meropenem-vaborbactam | + | – | – | – | – | – |
plazomicin | + | ± | + | ± | – | – |
colistin | ± | ± | ± | ± | ± | ± |
tigecycline | + | + | + | – | + | + |
- For KPC, the most common Class A carbapenemase, consider:
- For AmpCs, consider:
- For metallo-β-lactamases, consider:
- For all of the above, also consider:
- Eravacycline
- Tigecycline
- Colistin, though increasing resistance
- Plazomicin
- For carbapenem-resistant Pseudomonas aeruginosa, consider: