Antifungal spectrum of activity: Difference between revisions
From IDWiki
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{| class="wikitable" |
{| class="wikitable" |
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! Organism |
! Organism |
||
− | !align="center"| AmB |
+ | !align="center"| [[Amphotericin B|AmB]] |
− | !align="center"| Fluc |
+ | !align="center"| [[Fluconazole|Fluc]] |
− | !align="center"| Itra |
+ | !align="center"| [[Itraconazole|Itra]] |
− | !align="center"| Vori |
+ | !align="center"| [[Voriconazole|Vori]] |
− | !align="center"| Posa |
+ | !align="center"| [[Posaconazole|Posa]] |
− | !align="center"| Anidula |
+ | !align="center"| [[Anidulafungin|Anidula]] |
− | !align="center"| Caspo |
+ | !align="center"| [[Caspofungin|Caspo]] |
− | !align="center"| Mica |
+ | !align="center"| [[Micafungin|Mica]] |
− | !align="center"| Flucyt |
+ | !align="center"| [[Flucytasine|Flucyt]] |
|- |
|- |
||
− | | |
+ | | [[Aspergillus species]] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''A. flavus'' |
+ | | [[Aspergillus flavus|''A. flavus'']] |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''A. fumigatus'' |
+ | | [[Aspergillus fumigatus|''A. fumigatus'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''A. terreus'' |
+ | | [[Aspergillus terreus|''A. terreus'']] |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''A. niger'' |
+ | | [[Aspergillus niger|''A. niger'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | |
+ | | [[Candida species]] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
|- |
|- |
||
− | | ''C. albicans'' |
+ | | [[Candida albicans|''C. albicans'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
|- |
|- |
||
− | | ''C. glabrata'' |
+ | | [[Candida glabrata|''C. glabrata'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
|- |
|- |
||
− | | ''C. krusei'' |
+ | | [[Candida krusei|''C. krusei'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
|- |
|- |
||
− | | ''C. lusitaniae'' |
+ | | [[Candida lusitaniae|''C. lusitaniae'']] |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
|- |
|- |
||
− | | ''C. parapsilosis'' |
+ | | [[Candida parapsilosis|''C. parapsilosis'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
|- |
|- |
||
− | | ''C. tropicalis'' |
+ | | [[Candida tropicalis|''C. tropicalis'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
|- |
|- |
||
− | | |
+ | | [[Cryptococcus neoformans]] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
|- |
|- |
||
− | | ''Coccidioides'' |
+ | | [[Coccidioides imitis|''Coccidioides'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''Blastomyces'' |
+ | | [[Blastomyces dermatitidis|''Blastomyces'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''Histoplasma'' |
+ | | [[Histoplasma capsulatum|''Histoplasma'']] |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | |
+ | | [[Fusarium species]] |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''Scedosporium apiospermum'' |
+ | | ''[[Scedosporium apiospermum]]'' |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | ''Scedosporium prolificans'' |
+ | | ''[[Scedosporium prolificans]]'' |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|- |
|- |
||
− | | Zygomycetes |
+ | | [[Zygomycetes]] |
− | | |
+ | | style="text-align:center;background-color:lemonchiffon" | ± |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:lightgreen" | + |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
− | | |
+ | | style="text-align:center;background-color:indianred" | – |
|} |
|} |
||
Revision as of 20:41, 14 October 2019
Organism | AmB | Fluc | Itra | Vori | Posa | Anidula | Caspo | Mica | Flucyt |
---|---|---|---|---|---|---|---|---|---|
Aspergillus species | + | – | + | + | + | + | + | + | – |
A. flavus | ± | – | + | + | + | + | + | + | – |
A. fumigatus | + | – | + | + | + | + | + | + | – |
A. terreus | – | – | + | + | + | + | + | + | – |
A. niger | + | – | ± | + | + | + | + | + | – |
Candida species | + | + | + | + | + | + | + | + | + |
C. albicans | + | + | + | + | + | + | + | + | + |
C. glabrata | + | ± | ± | + | + | + | + | + | + |
C. krusei | + | – | ± | + | + | + | + | + | ± |
C. lusitaniae | – | + | + | + | + | + | + | + | + |
C. parapsilosis | + | + | + | + | + | ± | ± | ± | + |
C. tropicalis | + | + | + | + | + | + | + | + | + |
Cryptococcus neoformans | + | + | + | + | + | – | – | – | + |
Coccidioides | + | + | + | + | + | ± | ± | ± | – |
Blastomyces | + | + | + | + | + | ± | ± | ± | – |
Histoplasma | + | + | + | + | + | ± | ± | ± | – |
Fusarium species | ± | – | – | + | + | – | – | – | – |
Scedosporium apiospermum | ± | – | ± | + | + | – | – | – | – |
Scedosporium prolificans | – | – | – | ± | ± | – | – | – | – |
Zygomycetes | ± | – | – | – | + | – | – | – | – |
Aspergillus ustus is resistant to azoles and echinocandins, and variable resistance to amphotericin (though still susceptible to terbinafine)
Source: Elizabeth S. Dodds Ashley, Russell Lewis, James S. Lewis, Craig Martin, David Andes, Pharmacology of Systemic Antifungal Agents, Clinical Infectious Diseases, Volume 43, Issue Supplement_1, 1 August 2006, Pages S28–S39, https://doi.org/10.1086/504492