Antibiotic spectrum index: Difference between revisions
From IDWiki
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* For each patient, the number of points for every antibiotic is added to give a total daily ASI |
* For each patient, the number of points for every antibiotic is added to give a total daily ASI |
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| − | == Spectrum Indices == |
+ | == Sample Spectrum Indices == |
| − | {| class="wikitable" |
+ | {| class="wikitable sortable" |
!Antibiotic |
!Antibiotic |
||
!MSSA |
!MSSA |
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| Line 36: | Line 36: | ||
!ASI |
!ASI |
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|- |
|- |
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| − | |Dicloxacillin |
+ | |[[Dicloxacillin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 53: | Line 53: | ||
|1 |
|1 |
||
|- |
|- |
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| − | |Oxacillin |
+ | |[[Oxacillin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 70: | Line 70: | ||
|1 |
|1 |
||
|- |
|- |
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| − | |Amoxicillin |
+ | |[[Amoxicillin]] |
|0 |
|0 |
||
|1 |
|1 |
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| Line 87: | Line 87: | ||
|2 |
|2 |
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|- |
|- |
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| − | |Ampicillin |
+ | |[[Ampicillin]] |
|0 |
|0 |
||
|1 |
|1 |
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| Line 104: | Line 104: | ||
|2 |
|2 |
||
|- |
|- |
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| − | |Cephalexin |
+ | |[[Cephalexin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 121: | Line 121: | ||
|2 |
|2 |
||
|- |
|- |
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| − | |Erythromycin |
+ | |[[Erythromycin]] |
|0 |
|0 |
||
|0 |
|0 |
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| Line 138: | Line 138: | ||
|2 |
|2 |
||
|- |
|- |
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| − | |Erythromycin |
+ | |[[Erythromycin]] |
|0 |
|0 |
||
|0 |
|0 |
||
| Line 155: | Line 155: | ||
|2 |
|2 |
||
|- |
|- |
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| − | |Metronidazole |
+ | |[[Metronidazole]] |
|0 |
|0 |
||
|0 |
|0 |
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| Line 172: | Line 172: | ||
|2 |
|2 |
||
|- |
|- |
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| − | |Penicillin |
+ | |[[Penicillin]] |
|0 |
|0 |
||
|1 |
|1 |
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| Line 189: | Line 189: | ||
|2 |
|2 |
||
|- |
|- |
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| − | |Aztreonam |
+ | |[[Aztreonam]] |
|0 |
|0 |
||
|0 |
|0 |
||
| Line 206: | Line 206: | ||
|3 |
|3 |
||
|- |
|- |
||
| − | |Cefazolin |
+ | |[[Cefazolin]] |
|1 |
|1 |
||
|0 |
|0 |
||
| Line 223: | Line 223: | ||
|3 |
|3 |
||
|- |
|- |
||
| − | |Cefdinir |
+ | |[[Cefdinir]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 240: | Line 240: | ||
|3 |
|3 |
||
|- |
|- |
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| − | |Cefixime |
+ | |[[Cefixime]] |
|0 |
|0 |
||
|0 |
|0 |
||
| Line 257: | Line 257: | ||
|3 |
|3 |
||
|- |
|- |
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| − | |Cefpodoxime |
+ | |[[Cefpodoxime]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 274: | Line 274: | ||
|3 |
|3 |
||
|- |
|- |
||
| − | |Rifampin |
+ | |[[Rifampin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 291: | Line 291: | ||
|3 |
|3 |
||
|- |
|- |
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| − | |Azithromycin |
+ | |[[Azithromycin]] |
|1 |
|1 |
||
|0 |
|0 |
||
| Line 308: | Line 308: | ||
|4 |
|4 |
||
|- |
|- |
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| − | |Cefprozil |
+ | |[[Cefprozil]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 325: | Line 325: | ||
|4 |
|4 |
||
|- |
|- |
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| − | |Ceftazidime |
+ | |[[Ceftazidime]] |
|0 |
|0 |
||
|0 |
|0 |
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| Line 342: | Line 342: | ||
|4 |
|4 |
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|- |
|- |
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| − | |Cefuroxime |
+ | |[[Cefuroxime]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 359: | Line 359: | ||
|4 |
|4 |
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|- |
|- |
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| − | |Chloramphenicol |
+ | |[[Chloramphenicol]] |
|0 |
|0 |
||
|0 |
|0 |
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| Line 376: | Line 376: | ||
|4 |
|4 |
||
|- |
|- |
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| − | |Clarithromycin |
+ | |[[Clarithromycin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 393: | Line 393: | ||
|4 |
|4 |
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|- |
|- |
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| − | |Clindamycin |
+ | |[[Clindamycin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 410: | Line 410: | ||
|4 |
|4 |
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|- |
|- |
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| − | |Piperacillin |
+ | |[[Piperacillin]] |
|0 |
|0 |
||
|1 |
|1 |
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| Line 427: | Line 427: | ||
|4 |
|4 |
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|- |
|- |
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| + | |[[TMP-SMX]] |
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| − | |Trimethoprim- sulfamethoxazole |
||
|1 |
|1 |
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|0 |
|0 |
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| Line 444: | Line 444: | ||
|4 |
|4 |
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|- |
|- |
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| − | |Cefotaxime |
+ | |[[Cefotaxime]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 461: | Line 461: | ||
|5 |
|5 |
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|- |
|- |
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| − | |Cefoxitin |
+ | |[[Cefoxitin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 478: | Line 478: | ||
|5 |
|5 |
||
|- |
|- |
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| − | |Ceftriaxone |
+ | |[[Ceftriaxone]] |
|1 |
|1 |
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|0 |
|0 |
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| Line 495: | Line 495: | ||
|5 |
|5 |
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|- |
|- |
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| + | |[[Colistin]] |
||
| − | |Colistimethate |
||
|0 |
|0 |
||
|0 |
|0 |
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| Line 512: | Line 512: | ||
|5 |
|5 |
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|- |
|- |
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| − | |Daptomycin |
+ | |[[Daptomycin]] |
|1 |
|1 |
||
|1 |
|1 |
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| Line 529: | Line 529: | ||
|5 |
|5 |
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|- |
|- |
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| − | |Doxycycline |
+ | |[[Doxycycline]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 546: | Line 546: | ||
|5 |
|5 |
||
|- |
|- |
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| − | |Gentamicin |
+ | |[[Gentamicin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 563: | Line 563: | ||
|5 |
|5 |
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|- |
|- |
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| − | |Minocycline |
+ | |[[Minocycline]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 580: | Line 580: | ||
|5 |
|5 |
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|- |
|- |
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| − | |Telavancin |
+ | |[[Telavancin]] |
|1 |
|1 |
||
|1 |
|1 |
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| Line 597: | Line 597: | ||
|5 |
|5 |
||
|- |
|- |
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| − | |Tobramycin |
+ | |[[Tobramycin]] |
|1 |
|1 |
||
|0 |
|0 |
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| Line 614: | Line 614: | ||
|5 |
|5 |
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|- |
|- |
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| − | |Vancomycin |
+ | |[[Vancomycin]] |
|1 |
|1 |
||
|1 |
|1 |
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| Line 631: | Line 631: | ||
|5 |
|5 |
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|- |
|- |
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| − | |Amikacin |
+ | |[[Amikacin]] |
|1 |
|1 |
||
|0 |
|0 |
||
| Line 648: | Line 648: | ||
|6 |
|6 |
||
|- |
|- |
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| − | |Amoxicillin- |
+ | |[[Amoxicillin-clavulanic acid]] |
|1 |
|1 |
||
|1 |
|1 |
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| Line 665: | Line 665: | ||
|6 |
|6 |
||
|- |
|- |
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| − | |Ampicillin-sulbactam |
+ | |[[Ampicillin-sulbactam]] |
|1 |
|1 |
||
|1 |
|1 |
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| Line 682: | Line 682: | ||
|6 |
|6 |
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|- |
|- |
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| − | |Cefepime |
+ | |[[Cefepime]] |
|1 |
|1 |
||
|0 |
|0 |
||
| Line 699: | Line 699: | ||
|6 |
|6 |
||
|- |
|- |
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| − | |Linezolid |
+ | |[[Linezolid]] |
|1 |
|1 |
||
|1 |
|1 |
||
| Line 716: | Line 716: | ||
|6 |
|6 |
||
|- |
|- |
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| − | |Ticarcillin-clavulanate |
+ | |[[Ticarcillin-clavulanate]] |
|1 |
|1 |
||
|0 |
|0 |
||
| Line 733: | Line 733: | ||
|6 |
|6 |
||
|- |
|- |
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| − | |Ceftaroline |
+ | |[[Ceftaroline]] |
|1 |
|1 |
||
|1 |
|1 |
||
| Line 750: | Line 750: | ||
|8 |
|8 |
||
|- |
|- |
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| − | |Ciprofloxacin |
+ | |[[Ciprofloxacin]] |
|1 |
|1 |
||
|1 |
|1 |
||
| Line 767: | Line 767: | ||
|8 |
|8 |
||
|- |
|- |
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| − | |Piperacillin-tazobactam |
+ | |[[Piperacillin-tazobactam]] |
|1 |
|1 |
||
|1 |
|1 |
||
| Line 784: | Line 784: | ||
|8 |
|8 |
||
|- |
|- |
||
| − | |Ertapenem |
+ | |[[Ertapenem]] |
|1 |
|1 |
||
|0 |
|0 |
||
| Line 801: | Line 801: | ||
|9 |
|9 |
||
|- |
|- |
||
| − | |Levofloxacin |
+ | |[[Levofloxacin]] |
|1 |
|1 |
||
|1 |
|1 |
||
| Line 818: | Line 818: | ||
|9 |
|9 |
||
|- |
|- |
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| − | |Meropenem |
+ | |[[Meropenem]] |
|1 |
|1 |
||
|0 |
|0 |
||
| Line 835: | Line 835: | ||
|10 |
|10 |
||
|- |
|- |
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| − | |Moxifloxacin |
+ | |[[Moxifloxacin]] |
|1 |
|1 |
||
|1 |
|1 |
||
| Line 852: | Line 852: | ||
|10 |
|10 |
||
|- |
|- |
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| − | |Imipenem-cilastatin |
+ | |[[Imipenem-cilastatin]] |
|1 |
|1 |
||
|1 |
|1 |
||
| Line 869: | Line 869: | ||
|11 |
|11 |
||
|- |
|- |
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| − | |Tigecycline |
+ | |[[Tigecycline]] |
|1 |
|1 |
||
|1 |
|1 |
||
Revision as of 08:16, 22 September 2022
- Measures the spectrum of an antibiotic, with a range from 0 to 14
- One point for activity against each of the following:
- Methicillin-sensitive Staphylococcus aureus (MSSA)
- Methicillin-resistant Staphylococcus aureus (MRSA)
- Enterococcus faecalis
- Vancomycin-resistant Enterococcus faecalis (VRE)
- Escherichia coli or Klebsiella
- AmpC producers (Enterobacter, Serratia, and Citrobacter)
- Extended-spectrum β-lactamase (ESBL) E. coli/Klebsiella
- Pseudomonas aeruginosa
- Penicillin-resistant pneumococcus (PRP)
- Moraxella and Haemophilus influenzae
- Mycoplasma and Chlamydophila
- Anaerobes (in general)
- Bacteriodes fragilis (specifically)
- Multidrug-resistant organisms
- For each patient, the number of points for every antibiotic is added to give a total daily ASI
Sample Spectrum Indices
| Antibiotic | MSSA | Enterococcus | Anaerobes | Bacteroides | Moraxella/Haemophilus | Escherichia/Klebsiella | AmpC | ESBL | Pseudomonas | MRSA | Pen-R pneumococcus | VRE | Atypical | MDRO | ASI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dicloxacillin | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| Oxacillin | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| Amoxicillin | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Ampicillin | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Cephalexin | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Erythromycin | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 |
| Erythromycin | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 |
| Metronidazole | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Penicillin | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Aztreonam | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 |
| Cefazolin | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| Cefdinir | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| Cefixime | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| Cefpodoxime | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| Rifampin | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3 |
| Azithromycin | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
| Cefprozil | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Ceftazidime | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4 |
| Cefuroxime | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Chloramphenicol | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Clarithromycin | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
| Clindamycin | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4 |
| Piperacillin | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4 |
| TMP-SMX | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4 |
| Cefotaxime | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 5 |
| Cefoxitin | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Ceftriaxone | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 5 |
| Colistin | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 5 |
| Daptomycin | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 5 |
| Doxycycline | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5 |
| Gentamicin | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5 |
| Minocycline | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5 |
| Telavancin | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 5 |
| Tobramycin | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5 |
| Vancomycin | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 5 |
| Amikacin | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 6 |
| Amoxicillin-clavulanic acid | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| Ampicillin-sulbactam | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| Cefepime | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 6 |
| Linezolid | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 6 |
| Ticarcillin-clavulanate | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 |
| Ceftaroline | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 8 |
| Ciprofloxacin | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 8 |
| Piperacillin-tazobactam | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 8 |
| Ertapenem | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 9 |
| Levofloxacin | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 9 |
| Meropenem | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 10 |
| Moxifloxacin | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 10 |
| Imipenem-cilastatin | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 11 |
| Tigecycline | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 13 |
Further Reading
- Development and Application of an Antibiotic Spectrum Index for Benchmarking Antibiotic Selection Patterns Across Hospitals. Infect Control Hosp Epidemiol. 2017;38(8):993-997. doi: 10.1017/ice.2017.94.
