Acquired immunodeficiency: Difference between revisions

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|humoural (B cells)
  
|humoural (B cells)
 
|respiratory infections with [[Encapsulated bacteria|encapsulated organisms]], [[chronic diarrhea]], [[aseptic meningitis]]
  
|respiratory infections with [[Encapsulated bacteria|encapsulated organisms]], [[chronic diarrhea]], [[aseptic meningitis]]
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|[[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Giardia lamblia]], [[Campylobacter species]], [[Enterovirus|enteroviruses]]
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|[[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Giardia lamblia]], [[Campylobacter]], [[Enterovirus|enteroviruses]]
 
|-
  
|-
 
|phagocytic
  
|phagocytic
 
|recurrent [[Abscess|abscesses]], [[gingivitis]], [[Aphthous ulcer|aphthous ulcers]]
  
|recurrent [[Abscess|abscesses]], [[gingivitis]], [[Aphthous ulcer|aphthous ulcers]]
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|[[Staphylococcus aureus]], [[Burkholderia cepacia]], [[Serratia marcescens]], [[Aspergillus species]], [[Nocardia species]]
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|[[Staphylococcus aureus]], [[Burkholderia cepacia]], [[Serratia marcescens]], [[Aspergillus]], [[Nocardia]]
 
|-
  
|-
 
|monocytic
  
|monocytic
 
|disseminated infections and multifocal [[osteomyelitis]]
  
|disseminated infections and multifocal [[osteomyelitis]]
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|[[non-tuberculous mycobacteria]], [[Salmonella species]], [[Histoplasma capsulatum]], [[Coccidioides immitis]]
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|[[non-tuberculous mycobacteria]], [[Salmonella]], [[Histoplasma capsulatum]], [[Coccidioides immitis]]
 
|-
  
|-
 
|[[Toll-like receptors|TLR]]
  
|[[Toll-like receptors|TLR]]
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|complement
  
|complement
 
|recurrent [[bacteremia]] and [[meningitis]]
  
|recurrent [[bacteremia]] and [[meningitis]]
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|[[Neisseria species]]
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|[[Neisseria]]
 
|-
  
|-
 
|T cells and phagocytes
  
|T cells and phagocytes

Revision as of 22:49, 7 February 2022

Clinical Manifestations

Immune Defect Typical Infections Typical Organisms
cell-mediated (T cells) persistent viral infections, opportunistic infections, disseminated infections Pneumocystis jirovecii, Cryptococcus, Herpesviridae
humoural (B cells) respiratory infections with encapsulated organisms, chronic diarrhea, aseptic meningitis Haemophilus influenzae, Streptococcus pneumoniae, Giardia lamblia, Campylobacter, enteroviruses
phagocytic recurrent abscesses, gingivitis, aphthous ulcers Staphylococcus aureus, Burkholderia cepacia, Serratia marcescens, Aspergillus, Nocardia
monocytic disseminated infections and multifocal osteomyelitis non-tuberculous mycobacteria, Salmonella, Histoplasma capsulatum, Coccidioides immitis
TLR recurrent meningitis, bacteremia, absence of fever Streptococcus pneumoniae, Neisseria meningitidis, Staphylococcus aureus, HSV
complement recurrent bacteremia and meningitis Neisseria
T cells and phagocytes eczema, kyphoscoliosis, pathologic fratures, pulmonary and cutaneous infections, mucocutaneous candidiasis Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, Candida albicans

Differential Diagnosis

Cell-Mediated Immunodeficiency

Humoural Immunodeficiency

Phagocytic Defect

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